Prefrontal cortex (PFC) circuits are modulated by dopamine acting on D1‐and D2‐like
receptors, which are pharmacologically exploited to manage neuropsychiatric conditions …

The A2AR is largely coexpressed with D2Rs and enkephalin mRNA in the striatum where it
modulates dopaminergic activity. Activation of the A2AR antagonizes D2R-mediated …

Adenosine and dopamine (DA) strongly modulate the neuronal activity in the striatum by pre-
and postsynaptic mechanisms. As several behavioral and molecular studies indicate a …

G-protein coupled receptors interact to provide additional regulatory mechanisms for
neurotransmitter signaling. Adenosine A2A receptors are expressed at a high density in …

The function of striatal adenosine A 2A receptors (A 2A Rs) is well recognized because of
their high expression levels and the documented antagonistic interaction between A 2A Rs …

Adenosine A2A receptors (A2AR) are located postsynaptically in striatopallidal GABAergic
neurons, antagonizing dopamine D2 receptor functions, and are also located …

Basal ganglia processing results from a balanced activation of direct and indirect striatal
efferent pathways, which are controlled by dopamine D1 and D2 receptors, respectively …

Adenosine A2A receptors (A2ARs) are highly concentrated in the striatum. Two
pharmacological different functional populations of A2ARs have been recently described …

G protein‐coupled receptors (GPCR) exhibit the ability to form receptor complexes that
include molecularly different GPCR (ie, GPCR heteromers), which endow them with singular …

A2A adenosine receptors (A2ARs) are expressed with the greatest abundance in the
striatum and other nuclei of the basal ganglia. The segregated expression of A2ARs on the …