A very significant density of adenosine A2A receptors (A2ARs) is present in the striatum,
where they are preferentially localized postsynaptically in striatopallidal medium spiny …

Adenosine A2A (A2AR) and dopamine D2 (D2R) receptors mediate the antagonism
between adenosinergic and dopaminergic transmission in striatopallidal GABAergic …

Dopamine release is regulated by presynaptic dopamine receptors and interactions
between adenosine and dopamine receptors have been well documented. In the present …

A2A adenosine receptor antagonists are currently under investigation as potential
therapeutic agents for Parkinson's disease (PD). However, the molecular mechanisms …

The discovery of antagonistic interactions between A2A adenosine receptors and D2
dopamine receptors in the ventral striatum suggested that A2A receptor activation might …

Adenosine A2A and dopamine D2 receptors have been shown previously to form
heteromeric complexes and interact at the level of agonist binding, G protein coupling, and …

Dopamine D2 receptors (Rs) and adenosine A2ARs are coexpressed on striatopallidal
neurons, where they mediate opposing actions. In agreement with the idea that D2Rs …

A2A adenosine receptors are highly expressed in the striatum where they modulate
dopaminergic activity. The role of A2A receptors in psychostimulant action is less well …

The dopamine D1 and D2 receptors are major receptors in the regulation of striatal function
and striatal adenosine A1 and A2A receptors are major modulators of their signaling. The …

Adenosine A2A receptors (A2AR) are a sub-type of receptors enriched in basal ganglia,
activated by the neuromodulator adenosine, which interact with dopamine D2 receptors …