Recently, the adenosine A2A receptor (A2AR) has emerged as an attractive target for
Parkinson's disease (PD) treatment by virtue of its coexpression with the dopamine D2 …

Bursting activity of striatal medium spiny neurons results from membrane potential
oscillations between a down-and an upstate that could be regulated by G-protein-coupled …

Adenosine A2A receptors are most abundant in the striatum where they control the
striatopallidal pathway thus controlling locomotion. Extra-striatal A2A receptors are …

Antagonistic interactions between adenosine A2a and dopamine D2 receptors and between
adenosine A1 and dopamine D1 receptors have been previously found in the basal ganglia …

Adenosine antagonists potentiate dopamine-mediated behaviours. A2a adenosine and D2
dopamine receptors are abundantly co-expressed within the striatopallidal subset of striatal …

It is now generally accepted that astrocytes are active players in synaptic transmission, so
that a neurocentric perspective of the integrative signal communication in the central …

In the 1980s and 1990s, the concept was introduced that molecular integration in the Central
Nervous System could develop through allosteric receptor–receptor interactions in …

Adenosine A2A receptors are highly enriched in the basal ganglia system. They are
predominantly expressed in enkephalin-expressing GABAergic striatopallidal neurons and …

Recently evidence has been presented that adenosine A2A and dopamine D2 receptors
form functional heteromeric receptor complexes as demonstrated in human neuroblastoma …

Adenosine–dopamine interactions in the central nervous system (CNS) have been studied
for many years in view of their relevance for disorders of the CNS and their treatments. The …