Gene knockout approach to adenosine A2A receptors in Parkinson's disease
JF Chen, MA Schwarzschild - Drug development research, 2003 - Wiley Online Library
Recently, the adenosine A2A receptor (A2AR) has emerged as an attractive target for
Parkinson's disease (PD) treatment by virtue of its coexpression with the dopamine D2 …
Parkinson's disease (PD) treatment by virtue of its coexpression with the dopamine D2 …
Dopamine D2 and adenosine A2A receptors regulate NMDA-mediated excitation in accumbens neurons through A2A–D2 receptor heteromerization
Bursting activity of striatal medium spiny neurons results from membrane potential
oscillations between a down-and an upstate that could be regulated by G-protein-coupled …
oscillations between a down-and an upstate that could be regulated by G-protein-coupled …
Different synaptic and subsynaptic localization of adenosine A2A receptors in the hippocampus and striatum of the rat
Adenosine A2A receptors are most abundant in the striatum where they control the
striatopallidal pathway thus controlling locomotion. Extra-striatal A2A receptors are …
striatopallidal pathway thus controlling locomotion. Extra-striatal A2A receptors are …
Adenosine A1 receptor-dopamine D1 receptor interaction in the rat limbic system: modulation of dopamine D1 receptor antagonist binding sites
S Ferré, P Popoli, B Tinner-Staines, K Fuxe - Neuroscience letters, 1996 - Elsevier
Antagonistic interactions between adenosine A2a and dopamine D2 receptors and between
adenosine A1 and dopamine D1 receptors have been previously found in the basal ganglia …
adenosine A1 and dopamine D1 receptors have been previously found in the basal ganglia …
Adenosine antagonists potentiate D2 dopamine-dependent activation of Fos in the striatopallidal pathway
AE Pollack, JS Fink - Neuroscience, 1995 - Elsevier
Adenosine antagonists potentiate dopamine-mediated behaviours. A2a adenosine and D2
dopamine receptors are abundantly co-expressed within the striatopallidal subset of striatal …
dopamine receptors are abundantly co-expressed within the striatopallidal subset of striatal …
[HTML][HTML] Striatal astrocytic A2A-D2 receptor-receptor interactions and their role in neuropsychiatric disorders
It is now generally accepted that astrocytes are active players in synaptic transmission, so
that a neurocentric perspective of the integrative signal communication in the central …
that a neurocentric perspective of the integrative signal communication in the central …
Multiple adenosine-dopamine (A2A-D2 like) heteroreceptor complexes in the brain and their role in schizophrenia
DO Borroto-Escuela, L Ferraro, M Narvaez… - Cells, 2020 - mdpi.com
In the 1980s and 1990s, the concept was introduced that molecular integration in the Central
Nervous System could develop through allosteric receptor–receptor interactions in …
Nervous System could develop through allosteric receptor–receptor interactions in …
Adenosine A2A receptors and basal ganglia physiology
Adenosine A2A receptors are highly enriched in the basal ganglia system. They are
predominantly expressed in enkephalin-expressing GABAergic striatopallidal neurons and …
predominantly expressed in enkephalin-expressing GABAergic striatopallidal neurons and …
Receptor heteromerization in adenosine A2A receptor signaling: Relevance for striatal function and Parkinson's disease
K Fuxe, LF Agnati, K Jacobsen, J Hillion, M Canals… - Neurology, 2003 - AAN Enterprises
Recently evidence has been presented that adenosine A2A and dopamine D2 receptors
form functional heteromeric receptor complexes as demonstrated in human neuroblastoma …
form functional heteromeric receptor complexes as demonstrated in human neuroblastoma …
Adenosine–dopamine interactions in the pathophysiology and treatment of CNS disorders
K Fuxe, D Marcellino… - CNS neuroscience & …, 2010 - Wiley Online Library
Adenosine–dopamine interactions in the central nervous system (CNS) have been studied
for many years in view of their relevance for disorders of the CNS and their treatments. The …
for many years in view of their relevance for disorders of the CNS and their treatments. The …