Adenosine plays a very significant role in modulating striatal glutamatergic and
dopaminergic neurotransmission. In the present essay we first review the extensive …

The adenosine A2A receptor (A2AR) is a potential drug target for the treatment of
Parkinson's disease and other neurological disorders. In rodents, the therapeutic efficacy of …

Electrophysiological and pharmacological studies have demonstrated that alpha-1
adrenergic receptor (α1AR) activation facilitates dopamine (DA) transmission in the striatum …

Adenosine A2A receptors localized in the dorsal striatum are considered as a new target for
the development of antiparkinsonian drugs. Co-administration of A2A receptor antagonists …

Adenosine A2A-dopamine D2 receptor interactions play a very important role in striatal
function. A2A-D2 receptor interactions provide an example of the capabilities of information …

To investigate if adenosine A2A receptor stimulation in vivo modulates dopamine D3
receptor binding, we analyzed the effects of 2-[p-(carboxyethyl)-phenylethylamino]-5′-N …

Neuroleptics, which are potent dopamine receptor antagonists, are used to treat psychosis.
In the striatum, dopamine subtype‐2 (D2) receptors interact with high‐affinity adenosine …

The existence of A 2A-D 2 heteromeric complexes is based on coimmunoprecipitation
studies and on fluorescence resonance energy transfer and bioluminescence resonance …

A2A receptor is highly coexpressed with enkephalin and D2 receptor in striatopallidal
neurons. A2A antagonists acutely enhance motor behavior in animal models of Parkinson's …

Adenosine acts as a neuromodulator through A1 and A2 receptors. The adenosine analogs
have been recognized, among other effects, as strong depressors of the locomotor activity …