The interaction between adenosine A2A and dopamine D2 receptors in striatal neurons is a
well-established phenomenon and has opened up new perspectives on the molecular …

It is well known that the nucleoside adenosine exerts a modulatory influence in the central
nervous system by activating G protein coupled receptors. Adenosine A2A receptors, the …

It has been shown that striatal adenosine A2A receptors can antagonistically interact with
dopamine D2 receptors at the membrane level leading to a decrease in the affinity and …

Abstract γ-Aminobutyric acid A receptor (GABA AR)-mediated postsynaptic currents were
recorded in brain slices from substantia nigra pars reticulate neurons. The selective …

Adenosine A1 receptors are inhibitory G-protein coupled receptors that presynaptically
regulate neurotransmitter release, but their role in self-regulating adenosine release is not …

Striatal dopamine adenosine A2A and D2 receptors interact to modulate some aspects of
motor and motivational function. The demonstration of A2A/D2 receptor heteromerization in …

When striatal neurons are strongly activated they produce adenosine, which activates
nearby adenosine A1 receptors (A1Rs) and adenosine A2A receptors (A2ARs). Although …

Adenosine A1 and A2A receptors are expressed in striatal projection neurons (SPNs). A1
receptors are located in direct (dSPN) and indirect SPNs (iSNP). A2A receptors are only …

In the CNS, an antagonistic interaction has been shown between adenosine A2A and
dopamine D2 receptors (A2 AR s and D2Rs) that may be relevant both in normal and …

Adenosine receptors in the basal ganglia are implicated in regulation of dopamine function
and release. We investigated the interactions between dopamine receptors and adenosine …