α2A adrenergic receptors highly expressed in mesoprefrontal dopamine neurons
MP Castelli, S Spiga, A Perra, C Madeddu, G Mulas… - Neuroscience, 2016 - Elsevier
Abstract α2 adrenoreceptors (α2-ARs) play a key role in the control of noradrenaline and
dopamine release in the medial prefrontal cortex (mPFC). Here, using UV-laser …
dopamine release in the medial prefrontal cortex (mPFC). Here, using UV-laser …
Genetic blockade of adenosine A2A receptors induces cognitive impairments and anatomical changes related to psychotic symptoms in mice
M Moscoso-Castro, I Gracia-Rubio, F Ciruela… - European …, 2016 - Elsevier
Schizophrenia is a chronic severe mental disorder with a presumed neurodevelopmental
origin, and no effective treatment. Schizophrenia is a multifactorial disease with genetic …
origin, and no effective treatment. Schizophrenia is a multifactorial disease with genetic …
Dopamine–Adenosine Interactions in the Striatum and the Globus Pallidus: Inhibition of Striatopallidal Neurons through Either D2 or A2A Receptors Enhances …
C Le Moine, P Svenningsson… - Journal of …, 1997 - Soc Neuroscience
D1 receptors located on striatonigral neurons and D2 receptors located, together with
A2Areceptors, on striatopallidal neurons are known to interact functionally. Using in situ …
A2Areceptors, on striatopallidal neurons are known to interact functionally. Using in situ …
Stimulation of adenosine A1 receptors attenuates dopamine D1 receptor‐mediated increase of NGFI‐A, c‐fos and jun‐B mRNA levels in the dopamine‐denervated striatum and …
S Ferré, R Rimondini, P Popoli… - European Journal of …, 1999 - Wiley Online Library
Adenosine A1 receptors antagonistically and specifically modulate the binding and
functional characteristics of dopamine D1 receptors. In the striatum this interaction seems to …
functional characteristics of dopamine D1 receptors. In the striatum this interaction seems to …
Antagonistic interaction between adenosine A2A receptors and dopamine D2 receptors in the ventral striopallidal system. Implications for the treatment of …
S Ferré, WT O'connor, P Snaprud, U Ungerstedt… - Neuroscience, 1994 - Elsevier
Recent studies have shown the existence of a specific antagonistic interaction between
adenosine A 2a receptors and dopamine D 2 receptors in the brain. This A 2a-D 2 …
adenosine A 2a receptors and dopamine D 2 receptors in the brain. This A 2a-D 2 …
New Aspects of Physiological and Pathophysiological Functions of Adenosine A2A Receptor in Basal Ganglia
H Kase - Bioscience, biotechnology, and biochemistry, 2001 - Taylor & Francis
There is now growing interest in the functional role of adenosine A2A receptors. Their
distribution within the brain is restricted in the basal ganglia, particularly abundant in the …
distribution within the brain is restricted in the basal ganglia, particularly abundant in the …
Activation of Adensine A1 and A2A Receptors Modulates Dopamine D2 Receptor‐Induced Responses in Stably Transfected Human Neuroblastoma Cells
H Salim, S Ferré, A Dalal, RA Peterfreund… - Journal of …, 2000 - Wiley Online Library
Adenosine can influence dopaminergic neuro‐transmission in the basal ganglia via
postsynaptic inter‐action between adenosine A2A and dopamine D2 receptors. We have …
postsynaptic inter‐action between adenosine A2A and dopamine D2 receptors. We have …
[HTML][HTML] Effects of the adenosine A2A receptor antagonist KW6002 on the dopaminergic system, motor performance, and neuroinflammation in a rat model of …
K Prasad, EFJ de Vries, E van der Meiden… - …, 2024 - Elsevier
Abstract Adenosine A 2A-receptors (A 2A R) and dopamine D 2-receptors (D 2 R) are known
to work together in a synergistic manner. Inhibiting A 2A Rs by genetic or pharmacological …
to work together in a synergistic manner. Inhibiting A 2A Rs by genetic or pharmacological …
Competitive regulation of synaptic Ca2+ influx by D2 dopamine and A2A adenosine receptors
MJ Higley, BL Sabatini - Nature neuroscience, 2010 - nature.com
Striatal D2-type dopamine receptors (D2Rs) have been implicated in the pathophysiology of
neuropsychiatric disorders, including Parkinson's disease and schizophrenia. Although …
neuropsychiatric disorders, including Parkinson's disease and schizophrenia. Although …
Deletion of striatal adenosine A2A receptor spares latent inhibition and prepulse inhibition but impairs active avoidance learning
Following early clinical leads, the adenosine A2AR receptor (A2AR) has continued to attract
attention as a potential novel target for treating schizophrenia, especially against the …
attention as a potential novel target for treating schizophrenia, especially against the …