Abstract α2 adrenoreceptors (α2-ARs) play a key role in the control of noradrenaline and
dopamine release in the medial prefrontal cortex (mPFC). Here, using UV-laser …

Schizophrenia is a chronic severe mental disorder with a presumed neurodevelopmental
origin, and no effective treatment. Schizophrenia is a multifactorial disease with genetic …

D1 receptors located on striatonigral neurons and D2 receptors located, together with
A2Areceptors, on striatopallidal neurons are known to interact functionally. Using in situ …

Adenosine A1 receptors antagonistically and specifically modulate the binding and
functional characteristics of dopamine D1 receptors. In the striatum this interaction seems to …

Recent studies have shown the existence of a specific antagonistic interaction between
adenosine A 2a receptors and dopamine D 2 receptors in the brain. This A 2a-D 2 …

There is now growing interest in the functional role of adenosine A2A receptors. Their
distribution within the brain is restricted in the basal ganglia, particularly abundant in the …

Adenosine can influence dopaminergic neuro‐transmission in the basal ganglia via
postsynaptic inter‐action between adenosine A2A and dopamine D2 receptors. We have …

Abstract Adenosine A 2A-receptors (A 2A R) and dopamine D 2-receptors (D 2 R) are known
to work together in a synergistic manner. Inhibiting A 2A Rs by genetic or pharmacological …

Striatal D2-type dopamine receptors (D2Rs) have been implicated in the pathophysiology of
neuropsychiatric disorders, including Parkinson's disease and schizophrenia. Although …

Following early clinical leads, the adenosine A2AR receptor (A2AR) has continued to attract
attention as a potential novel target for treating schizophrenia, especially against the …