The influence of the thymidine (Thd) kinase (TK) of herpes simplex virus type 1 (HSV-1) on
the intracellular uptake and anabolism of nucleosides has been investigated. To compare …

(HSV-1) and Type 2 (HSV-2) TK were purified by differential affinity column chromatography
using procedures developed in our laborat~ ry~.~ with gel preparation similar to that …

Two TK+ acyclovir-resistant variants of herpes simplex virus (HSV)(S1 and Tr7) and one TK+
BVdU-resistant variant (B3) induce abnormal thymidine kinases with impaired ability to …

Herpes simplex virus mutant KG 111 contains a nonsense mutation at codon 44 of the viral
thymidine kinase (tk) gene and produces low amounts of a truncated tk polypeptide. We …

Abstract Treatment of herpes simplex virus type 1 (HSV-1) infected Vero, BHK, BHKtk− and
LMtk− cells with 5-iodo-5′-amino-2′, 5′-dideoxyuridine (AIdUrd) caused increased …

To identify the nucleotide changes that occur in drug-induced thymidine kinase (TK) mutants
of herpes simplex virus type 2 (HSV-2), we compared the nucleotide sequences of the tk …

Abstract Several 5-methoxymethyldeoxyuridine (MMdU)-resistant mutants of herpes simplex
virus type 1 (HSV1) were classified by measuring their sensitivities to the deoxythymidine …

The mechanism responsible for the decreased sensitivity of a clinical herpes simplex virus
type 1 (HSV-1) isolate, HSV-145, to (E)-5-(2-bromovinyl)-2′-deoxyuridine (BVDU) was …

The thymidine analog 5'-ethynylthymidine was a potent inhibitor of herpes simplex virus type
1 (strain KOS)-induced thymidine kinase with a Ki value of 0.09 microM. 5'-Ethynylthymidine …

To understand the mechanisms of antiviral drug resistance and to have a system to examine
the cytotoxicity of herpes simplex virus type 1 (HSV-1) inhibitors that are thymidine kinase …