Intracellular uptake of thymidine and antiherpetic drugs for thymidine kinase-deficient mutants of herpes simplex virus type 1
PK Bae, JH Kim, HS Kim, IK Chung, SG Paik, CK Lee - Antiviral research, 2006 - Elsevier
The influence of the thymidine (Thd) kinase (TK) of herpes simplex virus type 1 (HSV-1) on
the intracellular uptake and anabolism of nucleosides has been investigated. To compare …
the intracellular uptake and anabolism of nucleosides has been investigated. To compare …
[引用][C] A RATIONAL APPROACH TO THE DEVELOPMENT OF ANTIVIRAL CHEMOTHERAPY: ALTERNATIVE SUBSTRATES OF HERPES SIMPLEX VIRUS TYPE 1 …
YC Cheng - Annals of the New York Academy of Sciences, 1977 - Wiley Online Library
(HSV-1) and Type 2 (HSV-2) TK were purified by differential affinity column chromatography
using procedures developed in our laborat~ ry~.~ with gel preparation similar to that …
using procedures developed in our laborat~ ry~.~ with gel preparation similar to that …
Characterization of abnormal thymidine kinases induced by drug-resistant strains of herpes simplex virus type 1
BA Larder, YC Cheng, G Darby - Journal of General …, 1983 - microbiologyresearch.org
Two TK+ acyclovir-resistant variants of herpes simplex virus (HSV)(S1 and Tr7) and one TK+
BVdU-resistant variant (B3) induce abnormal thymidine kinases with impaired ability to …
BVdU-resistant variant (B3) induce abnormal thymidine kinases with impaired ability to …
Low levels of herpes simplex virus thymidine-thymidylate kinase are not limiting for sensitivity to certain antiviral drugs or for latency in a mouse model
DM Coen, AF Irmiere, JG Jacobson, KM Kerns - Virology, 1989 - Elsevier
Herpes simplex virus mutant KG 111 contains a nonsense mutation at codon 44 of the viral
thymidine kinase (tk) gene and produces low amounts of a truncated tk polypeptide. We …
thymidine kinase (tk) gene and produces low amounts of a truncated tk polypeptide. We …
Production of herpes simplex virus type 1 thymidine kinase in the presence of thymidine analogues
ML Zucker, WR Mancini, MJ Otto, JJS Lee, WH Prusoff - Antiviral research, 1986 - Elsevier
Abstract Treatment of herpes simplex virus type 1 (HSV-1) infected Vero, BHK, BHKtk− and
LMtk− cells with 5-iodo-5′-amino-2′, 5′-dideoxyuridine (AIdUrd) caused increased …
LMtk− cells with 5-iodo-5′-amino-2′, 5′-dideoxyuridine (AIdUrd) caused increased …
Nucleotide sequence changes in thymidine kinase gene of herpes simplex virus type 2 clones from an isolate of a patient treated with acyclovir
S Kit, M Sheppard, H Ichimura… - Antimicrobial agents …, 1987 - Am Soc Microbiol
To identify the nucleotide changes that occur in drug-induced thymidine kinase (TK) mutants
of herpes simplex virus type 2 (HSV-2), we compared the nucleotide sequences of the tk …
of herpes simplex virus type 2 (HSV-2), we compared the nucleotide sequences of the tk …
HSV1-specific thymidylate kinase activity in infected cells
V Veerisetty, GA Gentry - Intervirology, 1985 - karger.com
Abstract Several 5-methoxymethyldeoxyuridine (MMdU)-resistant mutants of herpes simplex
virus type 1 (HSV1) were classified by measuring their sensitivities to the deoxythymidine …
virus type 1 (HSV1) were classified by measuring their sensitivities to the deoxythymidine …
Analysis of the thymidine kinase of a herpes simplex virus type 1 isolate that exhibits resistance to (E)-5-(2-bromovinyl)-2′-deoxyuridine
BAJ Wilber, JJ Docherty - Journal of general virology, 1994 - microbiologyresearch.org
The mechanism responsible for the decreased sensitivity of a clinical herpes simplex virus
type 1 (HSV-1) isolate, HSV-145, to (E)-5-(2-bromovinyl)-2′-deoxyuridine (BVDU) was …
type 1 (HSV-1) isolate, HSV-145, to (E)-5-(2-bromovinyl)-2′-deoxyuridine (BVDU) was …
Demonstration of viral thymidine kinase inhibitor and its effect on deoxynucleotide metabolism in cells infected with herpes simplex virus
LM Nutter, SP Grill, GE Dutschman… - Antimicrobial agents …, 1987 - Am Soc Microbiol
The thymidine analog 5'-ethynylthymidine was a potent inhibitor of herpes simplex virus type
1 (strain KOS)-induced thymidine kinase with a Ki value of 0.09 microM. 5'-Ethynylthymidine …
1 (strain KOS)-induced thymidine kinase with a Ki value of 0.09 microM. 5'-Ethynylthymidine …
Establishment and use of a cell line expressing HSV-1 thymidine kinase to characterize viral thymidine kinase-dependent drug-resistance
JH Kim, JB Park, PK Bae, HS Kim, JK Ahn, CK Lee - Antiviral research, 2002 - Elsevier
To understand the mechanisms of antiviral drug resistance and to have a system to examine
the cytotoxicity of herpes simplex virus type 1 (HSV-1) inhibitors that are thymidine kinase …
the cytotoxicity of herpes simplex virus type 1 (HSV-1) inhibitors that are thymidine kinase …
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- antiherpetic drugs intracellular uptake
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- thymidine kinase substrate specificity
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- thymidine thymidylate low levels
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- acyclovir treatment substrate specificity
- immunocompromised patient substrate specificity