Rapid translocation of nanoparticles from the lung airspaces to the body

HS Choi, Y Ashitate, JH Lee, SH Kim, A Matsui… - Nature …, 2010 - nature.com
Nano-size particles show promise for pulmonary drug delivery, yet their behavior after
deposition in the lung remains poorly understood. In this study, a series of near-infrared …

Nanoparticle formulations in pulmonary drug delivery

MM Bailey, CJ Berkland - Medicinal research reviews, 2009 - Wiley Online Library
The advent of nanotechnology has reignited interest in the lungs as a major route of drug
delivery for both systemic and local treatments. The large surface area of the lungs and the …

Toxicological hazards of inhaled nanoparticles—potential implications for drug delivery

PJA Borm, W Kreyling - Journal of nanoscience and …, 2004 - ingentaconnect.com
Nanoparticles (NP), here defined as particles with a diameter smaller then 100 nm, are
increasingly used in different applications, including drug carrier systems and to pass organ …

Inhaled drug delivery: Past, present, and future

L Yue, X Zhang, C Zhao, R Chen, X Chen, L Rao - Nano Today, 2023 - Elsevier
Inhaled drug delivery has been an emerging route for the treatment of lung diseases with
clear advantages over oral and intravenous routes. However, the delivery efficacy is affected …

The Lord of the Lungs: The essential role of pulmonary surfactant upon inhalation of nanoparticles

C Garcia-Mouton, A Hidalgo, A Cruz… - European Journal of …, 2019 - Elsevier
The rapid development of nanotechnology is opening a huge world of promising
possibilities in healthcare, but this is also increasing the necessity to study the potential risk …

Inhalable nanoparticles delivery targeting alveolar macrophages for the treatment of pulmonary tuberculosis

J Chae, Y Choi, M Tanaka, J Choi - Journal of bioscience and …, 2021 - Elsevier
Pulmonary tuberculosis is a highly prevalent respiratory disease that affects approximately a
quarter of the world's population. The drug treatment protocol for tuberculosis is complex …

Nanocarriers as pulmonary drug delivery systems to treat and to diagnose respiratory and non respiratory diseases

M Smola, T Vandamme… - International journal of …, 2008 - Taylor & Francis
The purpose of this review is to discuss the impact of nanocarriers administered by
pulmonary route to treat and to diagnose respiratory and non respiratory diseases. Indeed …

Patented therapeutic drug delivery strategies for targeting pulmonary diseases

AK Thakur, DK Chellappan, K Dua… - Expert opinion on …, 2020 - Taylor & Francis
Introduction: Pulmonary route is one of the preferred routes for the administration of
therapeutically active agents for systemic as well as localized delivery. Chronic obstructive …

Physicochemical properties of nanoparticles regulate translocation across pulmonary surfactant monolayer and formation of lipoprotein corona

G Hu, B Jiao, X Shi, RP Valle, Q Fan, YY Zuo - ACS nano, 2013 - ACS Publications
Interaction with the pulmonary surfactant film, being the first line of host defense, represents
the initial bio-nano interaction in the lungs. Such interaction determines the fate of the …

Formulation and characterization of spray-dried powders containing nanoparticles for aerosol delivery to the lung

JOH Sham, Y Zhang, WH Finlay, WH Roa… - International journal of …, 2004 - Elsevier
Spray-drying is a common practice of powder preparation for a wide range of drugs. Spray-
dried powders can be used to deliver particles to the lungs via a dry powder inhaler (DPI) …