In vitro, in vivo and ex vivo models for studying particle deposition and drug absorption of inhaled pharmaceuticals

K Nahar, N Gupta, R Gauvin, S Absar, B Patel… - European journal of …, 2013 - Elsevier
Delivery of therapeutic agents via the pulmonary route has gained significant attention over
the past few decades because this route of administration offers multiple advantages over …

Nanoparticle-mediated pulmonary drug delivery: State of the art towards efficient treatment of recalcitrant respiratory tract bacterial infections

Z Huang, SN Kłodzińska, F Wan… - Drug delivery and …, 2021 - Springer
Recalcitrant respiratory tract infections caused by bacteria have emerged as one of the
greatest health challenges worldwide. Aerosolized antimicrobial therapy is becoming …

[HTML][HTML] Nanotechnology approaches for inhalation treatment of lung diseases

A Kuzmov, T Minko - Journal of controlled release, 2015 - Elsevier
Local administration of therapeutics by inhalation for treatment of lung diseases has the
ability to deliver drugs, nucleic acids and peptides specifically to the site of their action and …

Application of nanotechnology in drug delivery systems for respiratory diseases

MX Luo, S Hua, QY Shang - Molecular Medicine …, 2021 - spandidos-publications.com
Respiratory disease is a common disease with a high incidence worldwide, which is a
serious threat to human health, and is considered a societal and economic burden. The …

Micro-and nanocarrier-mediated lung targeting

BD Kurmi, J Kayat, V Gajbhiye… - Expert opinion on drug …, 2010 - Taylor & Francis
Importance of the field: Drug delivery to lungs appears to be an attractive proposition on
account of the large surface area of the alveolar region; it provides tremendous opportunities …

[图书][B] Particle-lung interactions

P Gehr, J Heyder, P Gehr, J Heyder - 2000 - api.taylorfrancis.com
The current and rightfully ever increasing concerns for air pollution associated with climate
changes, and its health effects, make this second edition of Particle-Lung Interactions …

Nano-and micro-based inhaled drug delivery systems for targeting alveolar macrophages

WH Lee, CY Loo, D Traini… - Expert opinion on drug …, 2015 - Taylor & Francis
Introduction: Macrophages are the most versatile cells in the hematopoietic system and are
strategically distributed in tissues to fight pathogens or other foreign particles. In the lung …

Toxicological Assessment of Inhaled Nanoparticles: Role of in Vivo, ex Vivo, in Vitro, and in Silico Studies

E Fröhlich, S Salar-Behzadi - International journal of molecular sciences, 2014 - mdpi.com
The alveolar epithelium of the lung is by far the most permeable epithelial barrier of the
human body. The risk for adverse effects by inhaled nanoparticles (NPs) depends on their …

Right or left: the role of nanoparticles in pulmonary diseases

X Lu, T Zhu, C Chen, Y Liu - International journal of molecular sciences, 2014 - mdpi.com
Due to the rapid development of the nanotechnology industry in the last decade,
nanoparticles (NPs) are omnipresent in our everyday life today. Many nanomaterials have …

Measurement techniques for respiratory tract deposition of airborne nanoparticles: a critical review

J Löndahl, W Möller, JH Pagels… - Journal of aerosol …, 2014 - liebertpub.com
Determination of the respiratory tract deposition of airborne particles is critical for risk
assessment of air pollution, inhaled drug delivery, and understanding of respiratory disease …