Insulin resistance is a major risk factor for numerous diseases, including type 2 diabetes and
cardiovascular disease. These disorders have dramatically increased in incidence with …

Insulin resistance is a metabolic disorder affecting multiple tissues and is a precursor event
to type 2 diabetes (T2D). As T2D affects over 425 million people globally, there is an …

Insulin resistance—an impairment in the ability of insulin to appropriately regulate glucose
and lipid metabolism—is an early and key defect associated with weight gain (obesity), type …

Insulin resistance is the pivotal pathogenic component of many metabolic diseases,
including type 2 diabetes mellitus, and is defined as a state of reduced responsiveness of …

Insulin resistance arises when the nutrient storage pathways evolved to maximize efficient
energy utilization are exposed to chronic energy surplus. Ectopic lipid accumulation in liver …

Most human cells utilize glucose as the primary substrate, cellular uptake requiring insulin.
Insulin signaling is therefore critical for these tissues. However, decrease in insulin …

Insulin resistance is a major player in the pathogenesis of the metabolic syndrome and type
2 diabetes, and yet, the mechanisms responsible for it remain poorly understood. Magnetic …

There is now much interest in the mechanisms by which altered lipid metabolism might
contribute to insulin resistance as is found in Syndrome X or in Type II diabetes. This review …

The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of
research into insulin action and resistance has issued. In the intervening century, some …

Insulin resistance is a major metabolic feature of obesity and is a key factor in the etiology of
a number of diseases, including type 2 diabetes. In this review, we discuss potential …