Lipotoxicity in skeletal muscle plays a critical role in the aetiology of insulin resistance and
type 2 diabetes mellitus by interference of lipid metabolites with insulin signalling and action …

Acute exercise can reverse muscle insulin resistance, but the mechanism (s) of action are
unknown. With the use of a hindlimb perfusion model, we have found that acute contraction …

Background The pathogenesis of insulin resistance in the absence of obesity is unknown. In
obesity, multiple stress kinases have been identified that impair the insulin signaling …

Insulin resistance is concomitant with type 2 diabetes, obesity, hypertension, and other
features of the metabolic syndrome. Because insulin resistance is associated with …

It is widely accepted that increasing adiposity is associated with insulin resistance and
increased risk of type 2 diabetes. The predominant paradigm used to explain this link is the …

Increased dietary fat intake and lipolysis result in excessive lipid availability, which relates to
impaired insulin sensitivity. Over the last years, several mechanisms possibly underlying …

Insulin resistance plays a major role in the pathogenesis of the metabolic syndrome and
type 2 diabetes, and yet the mechanisms responsible for it remain poorly understood …

Obesity is a frequent cause of insulin resistance and poses a major risk for diabetes.
Abnormal fat deposition within skeletal muscle has been identified as a mechanism of …

Nutritional excess is a major forerunner of type 2 diabetes. It enhances the secretion of
insulin, but attenuates insulin's metabolic actions in the liver, skeletal muscle and adipose …

Skeletal muscle insulin resistance in obesity associates with mitochondrial dysfunction, but
the causality of this association is controversial. This review evaluates mitochondrial models …