Mutations of oncogenes and tumor suppressor genes often lead to transformation of a
normal cell to become a malignant cell. However, most malignant cells cannot grow to a …

Angiogenesis is regulated by the balance of pro-angiogenic factors and angiogenesis
inhibitors, and the imbalance of these regulators is the cause of pathological angiogenesis …

Background Angiogenesis, the formation of new blood vessels from the endothelium of the
existing vasculature, is fundamental in tumor growth, progression, and metastasis. Inhibiting …

Publisher Summary As normal cells progress to tumorigenicity, they must develop two
distinct new characteristics not possessed by the normal cells from which they arise: they …

Like most embryonic tissues, tumors have the ability to build up their own blood vessel
networks. However, the architecture of tumor vessels is fundamentally different from that …

Angiogenesis is an essential process in tumor growth. The concept of angiogenesis, when
proposed by Folksman in 1971, had a great impact on cancer research and therapy, as the …

Angiogenesis plays an important role in the development of cancer since it allows for the
delivery of oxygen, nutrients, and growth factors as well as tumor dissemination to distant …

Tumor angiogenesis is essential for the growth of primary and metastatic tumors. This
process requires the coordinated activities of multiple factors and cell types. For tumors to …

Tumor angiogenesis is a fast growing sub-domain of angiogenesis research and tumor
biology. Basic mechanisms have been unraveled and many key players identified. For many …

Tumors undergo fast neovascularization to support the rapid proliferation of cancer cells.
Vasculature in tumors, unlike that in wound healing, is immature and affects the tumor …