Nuclear pore complexes guardians of the nuclear genome

M Capelson, C Doucet… - Cold Spring Harbor …, 2010 - symposium.cshlp.org
Eukaryotic cell function depends on the physical separation of nucleoplasmic and
cytoplasmic components by the nuclear envelope (NE). Molecular communication between …

Structure, maintenance, and regulation of nuclear pore complexes: the gatekeepers of the eukaryotic genome

M Raices, MA D'Angelo - Cold Spring Harbor …, 2022 - cshperspectives.cshlp.org
In eukaryotic cells, the genetic material is segregated inside the nucleus. This
compartmentalization of the genome requires a transport system that allows cells to move …

Functional interactions between nucleoporins and chromatin

Y Liang, MW Hetzer - Current opinion in cell biology, 2011 - Elsevier
As the gatekeepers of the eukaryotic cell nucleus, nuclear pore complexes (NPCs) mediate
all molecular trafficking between the nucleoplasm and the cytoplasm. In recent years …

The role of nuclear pores in gene regulation, development and disease

M Capelson, MW Hetzer - EMBO reports, 2009 - embopress.org
Nuclear‐pore complexes (NPCs) are large protein channels that span the nuclear envelope
(NE), which is a double membrane that encloses the nuclear genome of eukaryotes. Each of …

The nuclear pore complex and the genome: organizing and regulatory principles

P Pascual-Garcia, M Capelson - Current opinion in genetics & …, 2021 - Elsevier
The nuclear pore complex (NPC) is a massive nuclear envelope-embedded protein
complex, the canonical function of which is to mediate selective nucleocytoplasmic transport …

The multifunctional nuclear pore complex: a platform for controlling gene expression

C Ptak, JD Aitchison, RW Wozniak - Current opinion in cell biology, 2014 - Elsevier
In addition to their established roles in nucleocytoplasmic transport, the intimate association
of nuclear pore complexes (NPCs) with chromatin has long led to speculation that these …

One ring to rule them all? Structural and functional diversity in the nuclear pore complex

J Fernandez-Martinez, MP Rout - Trends in biochemical sciences, 2021 - cell.com
The nuclear pore complex (NPC) is the massive protein assembly that regulates the
transport of macromolecules between the nucleus and the cytoplasm. Recent breakthroughs …

Dynamics of nuclear pore complex organization through the cell cycle

G Rabut, P Lénárt, J Ellenberg - Current opinion in cell biology, 2004 - Elsevier
In eukaryotic cells, all macromolecules that traffic between the nucleus and the cytoplasm
cross the double nuclear membrane through nuclear pore complexes (NPCs). NPCs are …

[PDF][PDF] Acting out of character: regulatory roles of nuclear pore complex proteins

N Xylourgidis, M Fornerod - Developmental cell, 2009 - cell.com
Nuclear pore complexes (NPCs) mediate all selective bidirectional transport between the
nucleus and the cytoplasm. Additional functions for NPCs and their constituent proteins …

Dynamics and diverse functions of nuclear pore complex proteins

G Chatel, B Fahrenkrog - Nucleus, 2012 - Taylor & Francis
Nuclear pore complexes (NPCs) are best known for their central role in controlling the
molecular trafficking between the cytoplasm and the nucleus. NPCs are assembled from …