2′-O, 4′-C-Ethyleneoxy bridged 5-methyluridine (EoNA-T), possessing a seven-
membered linkage and an anomeric 4′-carbon, was synthesized and introduced into …

In this study, 2′-O, 4′-C-methyleneoxy-bridged nucleic acid, a unique consecutive three-
acetal-containing nucleic acid (TaNA), was designed. Pyrimidine derivatives of methylated …

The post-synthetic modification of an oligonucleotide is a powerful strategy for the synthesis
of various analogs of the oligonucleotide, aiming to achieve the desired functions. In this …

Bicyclic nucleoside analogues, 3′-O, 4′-C-methyleneuridine and-5-methyluridine, were
successfully incorporated into oligonucleotides via connection with 2′, 5′-phosphodiester …

A novel 2′-O, 4′-C-bridged nucleic acid, 3, 4-dihydro-2 H-pyran bridge moiety (DpNA),
with a dioxabicyclo [3.2. 1] oct-3-ene ring was designed. Construction of the dihydropyran …

2′-O-(2-Methoxyethyl)-5-(3-aminoprop-1-ynyl)-uridine phosphoramidite (MEPU) has been
synthesized from d-ribose and 5-iodouracil and incorporated into triplex-forming …

We synthesized thymidine derivatives of 2′-C, 4′-C-ethyleneoxy-bridged 2′-
deoxyribonucleic acids with an 8′-methyl group ((R)-Me-EoDNA and (S)-Me-EoDNA) and …

The synthesis of 6′ S-Me-2′-O, 4′-C-ethylene-bridged 5-methyluridine (6′ S-Me-ENA-
T) was achieved using visible light-mediated stereoselective radical cyclization as a key …

Three 2′-C, 4′-C-ethyleneoxy-bridged 2′-deoxyribonucleic acids possessing six-
membered bridges with 6′-oxygen and 8′-exocyclic methylene groups (methylene …

Oligonucleotides containing 2-thiouridine (s2U) in place of uridine form stable RNA
duplexes with complementary RNAs. Particularly, this modified nucleoside has proved to …