Objectives The impact of simvastatin (SMV), a cholesterol lowering drug, on bone
metabolism appears to involve complex interaction with cholesterol metabolites, hormones …

Aim The present study was carried out to evaluate the effect of 1.2% simvastatin gel as local
drug delivery (LDD) system on Gingival Crevicular Fluid (GCF) Interleukin-6 (IL-6) and …

Statins possess a wide variety of pleiotropic properties that are independent of their lipid-
lowering abilities such as attenuating inflammation, oxidative stress, coagulation, platelet …

Background: The current understanding of the pathogenesis of periodontal disease has
resulted in adjunctive use of various pharmacologic agents in periodontal therapy. The …

Simvastatin (SMV) are specific competitive inhibitors which are widely used to lower
cholesterol for the treatment of hyperlipidemia and arteriosclerosis. They have shown to …

Purpose. The objective of this study is to explore the relationship between the levels of
interleukin‐(IL‐) 6, tumor necrosis factor‐(TNF‐) α, and visfatin and simvastatin usage, in the …

Simvastatin (SMV) is a specific competitive inhibitor of 3-hydroxy-2-methylglutaryl coenzyme
A reductase that promotes bone formation. The present clinical trial was designed to …

Background: Periodontitis is an inflammatory disease that results in bone resorption creating
bony defects, which may cause tooth loss. Various drugs have been studied using local …

Background: Simvastatin (SMV), a new locally delivered drug of class statins, is a specific
competitive inhibitor of 3-hydroxy-2-methyl-glutaryl coenzyme A reductase. Statins, besides …

Objectives: Statins are the group of lipid-lowering drugs commonly used to control
cardiovascular and cerebrovascular diseases. Statins have potential anti-inflammatory effect …