p14ARF enhances cisplatin-induced apoptosis in human osteosarcoma cells in p53-independent pathway

X Huang, X Yuan, Z Chen, S Liang - Zhonghua yi xue za zhi, 2015 - europepmc.org
Objective To study effect of tumor suppressor p14ARF on cisplatin-induced apoptosis in
human osteosarcoma cells with its molecular mechanisms to provide evidences for …

p14ARF enhances chemosensitivity to cisplatin in human osteosarcoma U2OS cells through p53 apoptotic pathway

X Yuan, X Huang, Z Chen, S Liang… - Zhonghua yi xue za zhi, 2014 - europepmc.org
Objective To explore the effects of tumor suppressor p14ARF on chemosensitivity of human
osteosarcoma U2OS cells to cisplatin and elucidate its molecular mechanism. Methods …

P14ARF sensitizes human osteosarcoma cells to cisplatin-induced apoptosis in a p53-independent manner

XW Yuan, XF Zhu, XF Huang, PY Sheng… - Cancer Biology & …, 2007 - Taylor & Francis
The tumor suppressor p14ARF, encoded by the INK4a/ARF locus, is often disrupted in
human cancers. p14ARF triggers cell cycle arrest and sensitizes cells to apoptosis in the …

Apoptosis induced by adenovirus-mediated p14ARF expression in U2OS osteosarcoma cells is associated with increased Fas expression

M Kim, M Sgagias, X Deng, YJ Jung, T Rikiyama… - Biochemical and …, 2004 - Elsevier
The INK4A/ARF locus on chromosome 9 is a tumor suppressor gene frequently mutated in
human cancers. In order to study the effects of p14ARF expression in tumor cells, we …

Effects of overexpressingp14 ARF on the apoptosis in human melanoma cells irradiated with γ-ray

L Peng, W Zhang, H Liu, D He, P Gao - Chinese Science Bulletin, 2003 - Springer
Tumor suppressor ARF can induce cell cycle arrest or apoptosis by activating p53. In order
to explore the molecular mechanism of the induction of apoptosis by p14 ARF, a human …

Recombinant adenovirus-mediated p14ARF overexpression sensitizes human breast cancer cells to cisplatin

X Deng, M Kim, D Vandier, Y Jung, T Rikiyama… - Biochemical and …, 2002 - Elsevier
p14ARF, the alternative product from the human INK4a/ARF locus, is one of the major
targets for alterations in the development of human cancers. Overexpression of p14ARF …

pl4ARF upregulation of p53 and enhanced effects of 5-fluorouracil in pancreatic cancer

Q Zhang, Q Ni, J Gan, Z Shen, J Luo, C Jin… - Chinese medical …, 2003 - mednexus.org
Objective To investigate the synergistic antitumor effects of combined use of p14ARF gene
and 5-fluorouracil (5-Fu) in pancreatic cancer. Methods A human pancreatic cancer cell line …

Enforced expression of p14ARF induces p53-dependent cell cycle arrest but not apoptosis

S Gallagher, RF Kefford, H Rizos - Cell Cycle, 2005 - Taylor & Francis
Expression of the p14ARF tumour suppressor is induced by hyperproliferative signals
produced by RAS, MYC and other oncogenes. p14ARF quenches inappropriate mitogenic …

Azidothymidine and cisplatin increase p14ARF expression in OVCAR-3 ovarian cancer cell line

L Vaskivuo, J Rysä, J Koivuperä, P Myllynen… - Toxicology and applied …, 2006 - Elsevier
p14ARF tumor suppressor protein regulates p53 by interfering with mdm2–p53 interaction.
p14ARF is activated in response to oncogenic stimuli but little is known of the responses of …

Effect of p19ARF on growth and apoptosis of leukemia cells

X Bai, F Che, Y MA, J LI, J Zhai - Chinese Journal of …, 1986 - pesquisa.bvsalud.org
AIM: To study the effect of p19ARF on the biological behavior of human leukemia cells.
METHODS: p19ARF was cloned in eukaryotic expression vector pcDNA3. 1 and transferred …