The fibrin polymers formed in solution during the earliest phase of the fibrinogen–fibrin
conversion are shown to be stable soluble molecules at pH7. 4 and 0.15 m-or 0.3 m-NaCl …

The inhibition of blood clotting by degradation products of fibrinogen reflects an interference
with fibrin network formation. The original discovery that digestion of fibrinogen by plasmin …

The present day concept of the primary structure of fibrinogen is outlined. Cleavage of the
molecule with CNBr and plasmin has yielded a number of fragments which account for …

Generation of a fibrin clot from purified thrombin and fibrinogen is initiated by a proteolytic
reaction and proceeds by means of three reversible 1-6 steps: the thrombin-induced …

In THE PRECEDING PAPER (I), Lorand has described how the action of thrombin alters the
fibrinogen molecule. Peptides amounting to about 3 per cent of its nitrogen content are split …

Gerald F. Smith** and Nils U. Bang abstract: Two new findings are presented in this
report:(1) it was discovered that a low thrombin activity can convert fibrinogen (1-2 and 1-8) …

IN 1963 one of us (ALC) reportedl that native fibrin preparations bound fibrinogen from
solution or plasma and that so-called fraction fibrin, prepared from purified fibrinogen and …

D. Knoll, 1 R. Hantgan,® J. Williams, 11J. McDonagh, 1 and J. Hermans* abstract:
Polymerization of fibrin is inhibited in the presence of excess fibrinogen fragment D. This …

Fibrinogen inhibits the fibrin monomer polymerization at pH 6.8 (I 0.14; temperature 28°)
accelerates it at pH 5.7 and has no effect at pH 6.0. The mechanism of the acceleration is …

Fibrinogen: fibrin complexes have been previously described in various thrombotic
disorders. To evaluate further the properties of fibrinogen: fibrin complexes, and their in vitro …