Mitochondrial encephalomyopathy, lactic acidosis, and stroke‐like episodes (MELAS) is a
mitochondrial disease most usually caused by point mutations in tRNA genes encoded by …

Mutations in mitochondrial DNA cause a number of neurological diseases with defined
neuropathology; however, mutations in this genome have also been found to be important in …

Inactivation of constitutive autophagy results in the formation of cytoplasmic inclusions in
neurones, but the relationship between impaired autophagy and Lewy bodies (LBs) remains …

In this brief review, I have highlighted recent advances in several areas of mitochondrial
medicine, including mtDNA-related diseases, mendelian mitochondrial …

Background Peripheral neuropathies are often caused by disruption of genes responsible
for myelination or axonal transport. In particular, impairment in mitochondrial fission and …

Cells rely on efficient protein quality control systems (PQCs) to maintain proper activity of
mitochondrial proteins. As part of this system, the mitochondrial chaperone Hsp60 assists …

Mitochondria, the energy stations of the cell, are the only extranuclear organelles, containing
their own (mitochondrial) DNA (mtDNA) and the protein synthesizing machinery. The …

Mitochondria are dynamic organelles that constantly undergo fusion and fission to maintain
their normal functionality. Impairment of mitochondrial dynamics is implicated in various …

In neurons, mitochondria are enriched to provide energy and calcium buffering required for
synaptic transmission. Additionally, mitochondria localize to the synapse, where they are …

The mouse mutant “motoneuron disease 2”(MND2, mnd2 on Chr 6) was originally
characterized as a spinal muscular atrophy (SMA) because degenerating motoneurons …