[HTML][HTML] Age-related mitochondrial alterations in brain and skeletal muscle of the YAC128 model of Huntington disease
K Bečanović, M Asghar, I Gadawska… - npj Aging and …, 2021 - nature.com
Mitochondrial dysfunction and bioenergetics failure are common pathological hallmarks in
Huntington's disease (HD) and aging. In the present study, we used the YAC128 murine …
Huntington's disease (HD) and aging. In the present study, we used the YAC128 murine …
[HTML][HTML] Muscle mitochondrial uncoupling dismantles neuromuscular junction and triggers distal degeneration of motor neurons
L Dupuis, JL Gonzalez De Aguilar, A Echaniz-Laguna… - PloS one, 2009 - journals.plos.org
Background Amyotrophic lateral sclerosis (ALS), the most frequent adult onset motor neuron
disease, is associated with hypermetabolism linked to defects in muscle mitochondrial …
disease, is associated with hypermetabolism linked to defects in muscle mitochondrial …
[HTML][HTML] Mitochondrial dysfunction and neurodegeneration
V Tapias - Frontiers in Neuroscience, 2019 - frontiersin.org
Neurodegenerative diseases are incurable and inexorably progressive conditions that affect
the central nervous system and result in a selective pattern of neuronal death. Parkinson's …
the central nervous system and result in a selective pattern of neuronal death. Parkinson's …
[HTML][HTML] Mitochondrial neurodegeneration
M Zeviani, C Viscomi - Cells, 2022 - mdpi.com
Mitochondria are cytoplasmic organelles, which generate energy as heat and ATP, the
universal energy currency of the cell. This process is carried out by coupling electron …
universal energy currency of the cell. This process is carried out by coupling electron …
Current perspective of mitochondrial biology in Parkinson's disease
NA Kaidery, B Thomas - Neurochemistry International, 2018 - Elsevier
Parkinson's disease (PD) is one of the most common neurodegenerative movement disorder
characterized by preferential loss of dopaminergic neurons of the substantia nigra pars …
characterized by preferential loss of dopaminergic neurons of the substantia nigra pars …
Mitochondrial dynamics–fusion, fission, movement, and mitophagy–in neurodegenerative diseases
H Chen, DC Chan - Human molecular genetics, 2009 - academic.oup.com
Neurons are metabolically active cells with high energy demands at locations distant from
the cell body. As a result, these cells are particularly dependent on mitochondrial function …
the cell body. As a result, these cells are particularly dependent on mitochondrial function …
[HTML][HTML] Mitochondrial protein dysfunction in pathogenesis of neurological diseases
L Wang, Z Yang, X He, S Pu, C Yang, Q Wu… - Frontiers in Molecular …, 2022 - frontiersin.org
Mitochondria are essential organelles for neuronal function and cell survival. Besides the
well-known bioenergetics, additional mitochondrial roles in calcium signaling, lipid …
well-known bioenergetics, additional mitochondrial roles in calcium signaling, lipid …
[HTML][HTML] Loss of forebrain MTCH2 decreases mitochondria motility and calcium handling and impairs hippocampal-dependent cognitive functions
A Ruggiero, E Aloni, E Korkotian, Y Zaltsman… - Scientific reports, 2017 - nature.com
Abstract Mitochondrial Carrier Homolog 2 (MTCH2) is a novel regulator of mitochondria
metabolism, which was recently associated with Alzheimer's disease. Here we demonstrate …
metabolism, which was recently associated with Alzheimer's disease. Here we demonstrate …
Mitochondrial diseases
MJ Molnar, GG Kovacs - Handbook of clinical neurology, 2018 - Elsevier
Mitochondrial disorders represent a major challenge in medicine. Most of the mitochondrial
proteins are encoded by the nuclear DNA (nDNA), whereas a very small fraction is encoded …
proteins are encoded by the nuclear DNA (nDNA), whereas a very small fraction is encoded …
[HTML][HTML] Mitochondrial dynamism and the pathogenesis of Amyotrophic Lateral Sclerosis
M Cozzolino, S Rossi, A Mirra, MT Carrì - Frontiers in cellular …, 2015 - frontiersin.org
Research on mitochondria in the last years has been characterized by the fundamental
finding that the morphology of mitochondria is deeply connected to the regulation of a vast …
finding that the morphology of mitochondria is deeply connected to the regulation of a vast …