Mitochondrial dysfunction and bioenergetics failure are common pathological hallmarks in
Huntington's disease (HD) and aging. In the present study, we used the YAC128 murine …

Background Amyotrophic lateral sclerosis (ALS), the most frequent adult onset motor neuron
disease, is associated with hypermetabolism linked to defects in muscle mitochondrial …

Neurodegenerative diseases are incurable and inexorably progressive conditions that affect
the central nervous system and result in a selective pattern of neuronal death. Parkinson's …

Mitochondria are cytoplasmic organelles, which generate energy as heat and ATP, the
universal energy currency of the cell. This process is carried out by coupling electron …

Parkinson's disease (PD) is one of the most common neurodegenerative movement disorder
characterized by preferential loss of dopaminergic neurons of the substantia nigra pars …

Neurons are metabolically active cells with high energy demands at locations distant from
the cell body. As a result, these cells are particularly dependent on mitochondrial function …

Mitochondria are essential organelles for neuronal function and cell survival. Besides the
well-known bioenergetics, additional mitochondrial roles in calcium signaling, lipid …

Abstract Mitochondrial Carrier Homolog 2 (MTCH2) is a novel regulator of mitochondria
metabolism, which was recently associated with Alzheimer's disease. Here we demonstrate …

Mitochondrial disorders represent a major challenge in medicine. Most of the mitochondrial
proteins are encoded by the nuclear DNA (nDNA), whereas a very small fraction is encoded …

Research on mitochondria in the last years has been characterized by the fundamental
finding that the morphology of mitochondria is deeply connected to the regulation of a vast …