[HTML][HTML] Acidic microenvironment and bone pain in cancer-colonized bone

T Yoneda, M Hiasa, Y Nagata, T Okui, FA White - BoneKEy reports, 2015 - ncbi.nlm.nih.gov
Solid cancers and hematologic cancers frequently colonize bone and induce skeletal-
related complications. Bone pain is one of the most common complications associated with …

[HTML][HTML] Contribution of acidic extracellular microenvironment of cancer-colonized bone to bone pain

T Yoneda, M Hiasa, Y Nagata, T Okui… - Biochimica et Biophysica …, 2015 - Elsevier
Solid and hematologic cancer colonized bone produces a number of pathologies. One of the
most common complications is bone pain. Cancer-associated bone pain (CABP) is a major …

Involvement of acidic microenvironment in the pathophysiology of cancer-associated bone pain

T Yoneda, K Hata, M Nakanishi, M Nagae… - Bone, 2011 - Elsevier
Bone pain is one of the most common complications in cancer patients with bone
metastases. Although the mechanism of cancer-associated bone pain is poorly understood …

[HTML][HTML] Intratumoral acidosis fosters cancer-induced bone pain through the activation of the mesenchymal tumor-associated stroma in bone metastasis from breast …

G Di Pompo, S Lemma, L Canti, N Rucci, M Ponzetti… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Cancer-induced bone pain (CIBP) is common in patients with bone metastases (BM),
significantly impairing quality of life. The current treatments for CIBP are limited since they …

Acidic microenvironment created by osteoclasts causes bone pain associated with tumor colonization

M Nagae, T Hiraga, T Yoneda - Journal of bone and mineral metabolism, 2007 - Springer
Bone pain is one of the most common complications in cancer patients with bone
metastases. Previous findings that inhibitors of osteoclastic bone resorption such as …

Cancer–nerve interplay in cancer progression and cancer-induced bone pain

T Yoneda, M Hiasa, T Okui, K Hata - Journal of Bone and Mineral …, 2023 - Springer
Introduction Cancer-induced bone pain (CIBP) is one of the most common and debilitating
complications associated with bone metastasis. Although our understanding of the precise …

Cancer-induced bone pain: Mechanisms and models

AN Lozano-Ondoua, AM Symons-Liguori… - Neuroscience …, 2013 - Elsevier
Cancerous cells can originate in a number of different tissues such as prostate, breast and
lung, but often go undetected and are non-painful. Many types of cancers have a propensity …

Cause and effect of microenvironmental acidosis on bone metastases

S Avnet, G Di Pompo, S Lemma, N Baldini - Cancer and Metastasis …, 2019 - Springer
Skeletal involvement is a frequent and troublesome complication in advanced cancers. In
the process of tumor cells homing to the skeleton to form bone metastases (BM), different …

Bone cancer pain: causes, consequences, and therapeutic opportunities

P Mantyh - PAIN®, 2013 - Elsevier
Common cancers, including cancers of the breast, lung, and prostate, frequently metastasize
to multiple bones where they can cause significant and life-altering pain. Similar to cancer …

[HTML][HTML] Reciprocal interactions between osteoclasts and nociceptive sensory neurons in bone cancer pain

AS Andriessen, CR Donnelly, RR Ji - Pain Reports, 2021 - journals.lww.com
Many common cancers such as breast, prostate, and lung cancer metastasize to bones at
advanced stages, producing severe pain and functional impairment. At present, the current …