Osteoarthritis (OA) results from interaction among a number of complex biologic processes,
both degradative and reparative. There is a growing trend to view the joint as an entire …

Osteoarthritis (OA) has traditionally been defined as a prototypical non-inflammatory
arthropathy, but today there is compelling evidence to suggest that it has an inflammatory …

Osteoarthritis (OA) is highly prevalent and a leading cause of disability worldwide. Despite
the global burden of OA, diagnostic tests and treatments for the molecular or early …

Dysregulated bone remodeling occurs when there is an imbalance between bone resorption
and bone formation. In rheumatic diseases, including rheumatoid arthritis (RA) and …

Osteoarthritis (OA) is often a progressive and disabling disease, which occurs in the setting
of a variety of risk factors–such as advancing age, obesity and trauma–that collude to incite …

Objective Joint health is affected by local and systemic hormones. It is well accepted that
systemic factors regulate the metabolism of joint tissues, and that substantial cross-talk …

Osteoarthritis, a degenerative joint disease, is the most disabling condition of the Western
world. It affects first and foremost the articular cartilages and leads to a molecular and …

Osteoarthritis (OA) is considered to be primarily a disease of the hyaline articular cartilage,
which secondarily affects subchondral bone and synovial membrane. The exact nature and …

Highlights•Osteoarthritis (OA) is a common and debilitating disease with no effective
treatments.•Articular chondrocyte behavior and matrix maintenance are major targets.•The …

Despite increasing evidence that subchondral bone contributes to osteoarthritis (OA)
pathogenesis, little is known about local changes in bone structure compared to cartilage …