Osteoarthritis (OA) is associated with cartilage degeneration and an accompanying
inflammatory syndrome of the synovium in addition to alteration of the subchondral bone …

Objective Osteoarthritis research is traditionally concentrating on events within the
degenerated articular cartilage. Changes in the synovial membrane are largely neglected. In …

Bone, not cartilage, should be the major focus in osteoarthritis | Nature Reviews Rheumatology
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Osteoarthritis (OA) involves all the structures of the joint. How the disease is initiated and
what factors trigger the disease process remain unclear, although the mechanical …

Introduction Osteoporosis (OP) increases cartilage damage in a combined rabbit model of
OP and osteoarthritis (OA). Accordingly, we assessed whether microstructure impairment at …

There is increasing recognition that osteoarthritis (OA) is a complex disease involving the
whole synovial joint, rather than the articular cartilage alone, however its aetiology and …

Osteoarthritis (OA) is the most well-known degenerative disease among the geriatric and is
a main cause of significant disability in daily living. It has a multifactorial etiology and is …

Objective Subchondral bone and the osteochondral junction are thought to contribute to
osteoarthritis (OA) knee pain. We undertook this study to identify osteochondral pathologies …

Rheumatoid arthritis is characterized by synovial inflammation and irreversible bone
erosions, both highlighting the immense reciprocal relationship between the immune and …

It is increasingly recognized that the pathogenesis of cartilage degradation in osteoarthritis
(OA) is multifactorial and involves the interactions between cartilage and its surrounding …