Senescence is a form of cell cycle arrest induced by stress such as DNA damage and
oncogenes. However, while arrested, senescent cells secrete a variety of proteins …

Cellular senescence is historically associated with cancer suppression and aging. Recently,
the reach of the senescence genetic program has been extended to include the ability of …

Cellular senescence, a state of stable cell cycle arrest in response to cellular stress, is an
indispensable mechanism to counter tumorigenesis by halting the proliferation of damaged …

Cellular senescence is a state of irreversible cell cycle arrest that can be induced by a
variety of potentially oncogenic stimuli, including DNA damage. Hence, senescence has …

In response to a variety of stresses, mammalian cells undergo a persistent proliferative
arrest known as cellular senescence. Many senescence‐inducing stressors are potentially …

Senescence is a permanent state of cell cycle arrest that—unlike quiescence—is
unresponsive to growth factors. Originally described in terms of the replicative exhaustion of …

“Cellular senescence” is a state in which cells undergo irreversible cell cycle arrest in
response to a variety of cellular stresses. Once cells senesce, they are strongly resistant to …

Cellular senescence is an established tumour-suppressive mechanism that prevents the
proliferation of premalignant cells. However, several lines of evidence show that senescent …

Introduction: Cellular senescence is a stable form of cell cycle exit. Though they no longer
divide, senescent cells remain metabolically active and secrete a plethora of proteins …

Cellular senescence is a stress response that elicits a permanent cell cycle arrest and
triggers profound phenotypic changes such as the production of a bioactive secretome …