Gut microbiome-targeted modulations regulate metabolic profiles and alleviate altitude-related cardiac hypertrophy in rats

Y Hu, Z Pan, Z Huang, Y Li, N Han… - Microbiology …, 2022 - Am Soc Microbiol
It is well known that humans physiologically or pathologically respond to high altitude, with
these responses accompanied by alterations in the gut microbiome. To investigate whether …

Alterations in gut microbiota and metabolites associated with altitude-induced cardiac hypertrophy in rats during hypobaric hypoxia challenge

Z Pan, Y Hu, Z Huang, N Han, Y Li, X Zhuang… - Science China Life …, 2022 - Springer
The gut microbiota is involved in host responses to high altitude. However, the dynamics of
intestinal microecology and their association with altitude-related illness are poorly …

Acute exposure to simulated high-altitude hypoxia alters gut microbiota in mice

F Wang, H Zhang, T Xu, Y Hu, Y Jiang - Archives of Microbiology, 2022 - Springer
Gut microbiota bears adaptive potential to different environments, but little is known
regarding its responses to acute high-altitude exposure. This study aimed to evaluate the …

Changes in the gut microbiota of rats in high-altitude hypoxic environments

X Bai, G Liu, J Yang, J Zhu, Q Wang, Y Zhou… - Microbiology …, 2022 - Am Soc Microbiol
This study was conducted to investigate the effects of high-altitude hypoxic environments on
the gut microbiota. Male Sprague-Dawley rats were randomly divided into three groups …

[HTML][HTML] Short-term chronic intermittent hypobaric hypoxia alters gut microbiota composition in rats

YM Tian, G Yue, SY Tian, Y Fang, L Zhang… - Biomedical and …, 2018 - html.rhhz.net
Chronic intermittent hypobaric hypoxia (CIHH) is a treatment of moderate hypoxia that
simulates high altitude interrupted by normoxia. Growing evidence shows that CIHH has …

[HTML][HTML] Antibiotic intervention exacerbated oxidative stress and inflammatory responses in SD rats under hypobaric hypoxia exposure

Y Liao, Z Chen, Y Yang, D Shen, S Chai, Y Ma… - Free Radical Biology …, 2023 - Elsevier
The gut microbiota plays a crucial role in maintaining host nutrition, metabolism, and
immune homeostasis, particularly in extreme environmental conditions. However, the …

Hyperbaric oxygen improves depression‐like behaviors in chronic stress model mice by remodeling gut microbiota and regulating host metabolism

B Zhang, W Dong, Z Ma, S Duan, R Han… - CNS Neuroscience …, 2023 - Wiley Online Library
Aims There is growing evidence that the gut microbiota plays a significant part in the
pathophysiology of chronic stress. The dysbiosis of the gut microbiota closely relates to …

[HTML][HTML] Dynamics of the gut microbiota in rats after hypobaric hypoxia exposure

Y Han, J Xu, Y Yan, X Zhao - PeerJ, 2022 - peerj.com
Background Gut microbiota plays an important role in host health and is influenced by
multiple factors. Hypobaric hypoxia usually existing at high altitude conditions can adversely …

Gut microbiota imbalance mediates intestinal barrier damage in high‐altitude exposed mice

Y Wang, Y Shi, W Li, S Wang, J Zheng, G Xu… - The FEBS …, 2022 - Wiley Online Library
The environmental conditions in high‐altitude areas can induce gastrointestinal disorders
and changes in gut microbiota. The gut microbiota is closely related to a variety of …

[HTML][HTML] Prebiotic administration modulates gut microbiota and faecal short-chain fatty acid concentrations but does not prevent chronic intermittent hypoxia-induced …

KM O'Connor, EF Lucking, TFS Bastiaanssen… - …, 2020 - thelancet.com
Background Evidence is accruing to suggest that microbiota-gut-brain signalling plays a
regulatory role in cardiorespiratory physiology. Chronic intermittent hypoxia (CIH), modelling …