[HTML][HTML] Molecular and biotechnological aspects of secondary metabolites in actinobacteria

R Salwan, V Sharma - Microbiological research, 2020 - Elsevier
The ability to produce plethora of secondary metabolites and enzymes for pharmaceutical,
agricultural and biotechnological applications make actinobacteria one of the most explored …

Biodiversity of secondary metabolites compounds isolated from phylum actinobacteria and its therapeutic applications

MM Al-Shaibani, RMS Radin Mohamed, NM Sidik… - Molecules, 2021 - mdpi.com
The current review aims to summarise the biodiversity and biosynthesis of novel secondary
metabolites compounds, of the phylum Actinobacteria and the diverse range of secondary …

Microbiological and molecular insights on rare Actinobacteria harboring bioactive prospective

DH Amin, NA Abdallah, A Abolmaaty, S Tolba… - Bulletin of the National …, 2020 - Springer
Background Actinobacteria is as a group of advanced filamentous bacteria. Rare
Actinobacteria are of special interest as they are rarely isolated from the environments. They …

[HTML][HTML] Actinobacteria in natural products research: Progress and prospects

PA Jose, A Maharshi, B Jha - Microbiological research, 2021 - Elsevier
Actinobacteria are well-recognised biosynthetic factories that produce an extensive
spectrum of secondary metabolites. Recent genomic insights seem to impact the exploitation …

Ecology and genomics of Actinobacteria: new concepts for natural product discovery

DA van Bergeijk, BR Terlouw, MH Medema… - Nature Reviews …, 2020 - nature.com
Actinobacteria constitute a highly diverse bacterial phylum with an unrivalled metabolic
versatility. They produce most of the clinically used antibiotics and a plethora of other natural …

[HTML][HTML] Activation of microbial secondary metabolic pathways: Avenues and challenges

B Baral, A Akhgari, M Metsä-Ketelä - Synthetic and Systems Biotechnology, 2018 - Elsevier
Microbial natural products are a tremendous source of new bioactive chemical entities for
drug discovery. Next generation sequencing has revealed an unprecedented genomic …

Genomic basis for natural product biosynthetic diversity in the actinomycetes

M Nett, H Ikeda, BS Moore - Natural product reports, 2009 - pubs.rsc.org
Covering: up to mid-2009 The phylum Actinobacteria hosts diverse high G+ C, Gram-
positive bacteria that have evolved a complex chemical language of natural product …

Concepts and methods to access novel antibiotics from actinomycetes

JJ Hug, CD Bader, M Remškar, K Cirnski, R Müller - Antibiotics, 2018 - mdpi.com
Actinomycetes have been proven to be an excellent source of secondary metabolites for
more than half a century. Exhibiting various bioactivities, they provide valuable approved …

Prospecting for new bacterial metabolites: a glossary of approaches for inducing, activating and upregulating the biosynthesis of bacterial cryptic or silent natural …

JS Zarins-Tutt, TT Barberi, H Gao… - Natural product …, 2016 - pubs.rsc.org
Covering: up to 2015 Over the centuries, microbial secondary metabolites have played a
central role in the treatment of human diseases and have revolutionised the pharmaceutical …

[HTML][HTML] Elicitation of secondary metabolism in actinomycetes

UR Abdelmohsen, T Grkovic, S Balasubramanian… - Biotechnology …, 2015 - Elsevier
Genomic sequence data have revealed the presence of a large fraction of putatively silent
biosynthetic gene clusters in the genomes of actinomycetes that encode for secondary …