Liver plays a central role in xenobiotics metabolism, thus affecting the in vivo disposition and
therapeutic effects of drugs. Carboxylesterases (CESs), with the main isoforms CES1 and …

The age-associated alteration in expression levels of carboxylesterases (CESs) can affect
both intestinal and hepatic first-pass metabolism after oral administration of xenobiotic esters …

Carboxylesterases (CESs) located in the intestine play an unique role in the absorption of
many drugs especially ester prodrugs. In order to determine the expression and hydrolyzing …

Carboxylesterase (CES) is important for the detoxification of a wide range of drugs and
xenobiotics. In this study, the hepatic level of CES2 mRNA was examined in cynomolgus …

Carboxylesterases constitute a class of enzymes that hydrolyze drugs containing such
functional groups as carboxylic acid ester, amide, and thioester. Hydrolysis of many drugs is …

Carboxylesterase (CES) 1 is the predominant esterase expressed in the human liver and is
capable of catalyzing the hydrolysis of a wide range of therapeutic agents, toxins, and …

The aims of this study were to develop a robust method for simultaneous quantification of
carboxylesterases (CESs) 1 and 2 and to quantify those absolute protein levels in human …

Human carboxylesterase (CES) 1 and CES2 are members of the serine hydrolase
superfamily, and both exhibit broad substrate specificity and are involved in xenobiotic and …

Carboxylesterase (CES) 1 and CES2 are two major hepatic hydrolases responsible for the
metabolism of numerous endogenous and exogenous compounds. In this study, age-and …

The induction of drug-metabolizing enzymes by chemicals is one of the major reasons for
drug-drug interactions. In the present study, the regulation of mRNA expression of one …