Curcumin modulates the inflammatory response and inhibits subsequent fibrosis in a mouse model of viral-induced acute respiratory distress syndrome

S Avasarala, F Zhang, G Liu, R Wang, SD London… - PloS one, 2013 - journals.plos.org
Acute Respiratory Distress Syndrome (ARDS) is a clinical syndrome characterized by diffuse
alveolar damage usually secondary to an intense host inflammatory response of the lung to …

The inhibitory effect of curcumin on virus-induced cytokine storm and its potential use in the associated severe pneumonia

Z Liu, Y Ying - Frontiers in cell and developmental biology, 2020 - frontiersin.org
Coronavirus infection, including SARS-CoV, MERS-CoV, and SARS-CoV2, causes daunting
diseases that can be fatal because of lung failure and systemic cytokine storm. The …

Curcumin ameliorates severe influenza pneumonia via attenuating lung injury and regulating macrophage cytokines production

S Han, J Xu, X Guo, M Huang - Clinical and Experimental …, 2018 - Wiley Online Library
Curcumin, an active phenolic agent extract from the Curcuma longa, exhibits excellent anti‐
cancer, anti‐inflammation, and neuroprotective effects. We aimed to investigate the anti …

[HTML][HTML] Direct pulmonary delivery of solubilized curcumin reduces severity of lethal pneumonia

B Zhang, S Swamy, S Balijepalli, S Panicker… - The FASEB …, 2019 - ncbi.nlm.nih.gov
Acute respiratory distress syndrome (ARDS), the most severe form of acute lung injury, is
associated with reduced lung compliance and hypoxemia. Curcumin exhibits potent anti …

Anti-inflammatory effects of curcumin in acute lung injury: In vivo and in vitro experimental model studies

Y Wang, Y Wang, N Cai, T Xu, F He - International Immunopharmacology, 2021 - Elsevier
Inflammation plays a major role in the pathogenesis of acute lung injury (ALI), but the
mechanism remains unclear. Current anti-inflammatory therapy has poor efficacy on ALI …

Curcumin inhibits lipopolysaccharide (LPS)-induced endotoxemia and airway inflammation through modulation of sequential release of inflammatory mediators (TNF …

A Kumari, D Dash, R Singh - Inflammopharmacology, 2017 - Springer
Objective Curcumin (diferuloylmethane), a major component of turmeric is well known for its
anti-inflammatory potential. Present study investigates sequential release of inflammatory …

[HTML][HTML] Curcumin regulates the differentiation of naïve CD4+ T cells and activates IL-10 immune modulation against acute lung injury in mice

Y Chai, Y Chen, S Lin, K Xie, C Wang, Y Yang… - Biomedicine & …, 2020 - Elsevier
Objectives Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is one type of
respiratory failure characterized by rapid onset of widespread inflammation in the lungs …

Pulmonary administration of a water-soluble curcumin complex reduces severity of acute lung injury

MV Suresh, MC Wagner, GR Rosania… - American journal of …, 2012 - atsjournals.org
Local or systemic inflammation can result in acute lung injury (ALI), and is associated with
capillary leakage, reduced lung compliance, and hypoxemia. Curcumin, a plant-derived …

Anti-inflammatory effects of novel curcumin analogs in experimental acute lung injury

Y Zhang, D Liang, L Dong, X Ge, F Xu, W Chen… - Respiratory …, 2015 - Springer
Background Acute lung injury (ALI) and its most severe form acute respiratory distress
syndrome (ARDS) have been the leading cause of morbidity and mortality in intensive care …

Curcumin Ameliorates Cardiac Fibrosis by Regulating Macrophage-Fibroblast Crosstalk via IL18-P-SMAD2/3 Signaling Pathway Inhibition

J Zhao, Y Chen, Q Chen, T Hong, Z Zhong… - Frontiers in …, 2022 - frontiersin.org
Ethnopharmacological relevance: Curcumin is a bright yellow chemical produced by plants
of the Curcuma longa species. Chemically, curcumin is a diarylheptanoid, belonging to the …