Pyroptosis is identified as a pro-inflammatory programmed cell death, mediated by
gasdermins (GSDMs) family of proteins accompanied by pro-inflammatory signals release …

Stroke is a common disease with high mortality and disability worldwide. Different forms of
cell deaths, including apoptosis and necrosis, occur in ischemic or hemorrhagic brain tissue …

Pyroptosis is a form of programmed cell death mediated by gasdermin and is a product of
continuous cell expansion until the cytomembrane ruptures, resulting in the release of …

Pyroptosis is the process of inflammatory cell death. The primary function of pyroptosis is to
induce strong inflammatory responses that defend the host against microbe infection …

Acute kidney injury (AKI) is a worldwide problem, and there is no effective drug to eliminate
AKI. The death of renal cells is an important pathological basis of intrinsic AKI. At present …

Sepsis is defined as a life‐threatening disease involving multiple organ dysfunction caused
by dysregulated host responses to infection. To date, sepsis remains a dominant cause of …

Pyroptosis, a novel form of programmed cell death (PCD) discovered after apoptosis and
necrosis, is characterized by cell swelling, cytomembrane perforation and lysis, chromatin …

Diabetic nephropathy (DN), a sterile inflammatory disease, is a serious complication of
diabetes mellitus. However, recent evidence indicates that pyroptosis, a new term for pro …

Background Unraveling the mystery of cell death is one of the most fundamental progresses
of life sciences during the past decades. Regulated cell death (RCD) or programmed cell …

Pyroptosis is a programmed necrotic cell death executed by gasdermins, a family of pore-
forming proteins. The cleavage of gasdermins by specific proteases enables their pore …