There are at least three major reasons for thinking that iron participates in the mechanism of
nerve cell death in Parkinson's disease (PD):(1) Iron catalyzes the formation of highly toxic …

In vivo and post-mortem studies have demonstrated that increased nigral iron content in
patients with Parkinson's disease is a prominent pathophysiological feature. However, the …

The key molecular events that provoke Parkinson's disease (PD) are not fully understood.
Iron deposit was found in the substantia nigra pars compacta (SNpc) of PD patients and …

Postmortem demonstration of increased iron in the substantia nigra (SN) is a well‐
appreciated finding in Parkinson's disease (PD). Iron facilitates generation of free radicals …

Dysfunction of iron metabolism, which includes its uptake, storage, and release, plays a key
role in neurodegenerative disorders, including Parkinson's disease (PD), Alzheimer's …

Dopamine metabolism, alpha-synuclein pathology, and iron homeostasis have all been
implicated as potential contributors to the unique vulnerability of substantia nigra …

Background Preliminary studies have shown an increase in iron accumulation in the
substantia nigra but not in the hippocampus in patients with Parkinson disease without …

Background Although levels of iron are known to be increased in the brains of patients with
Parkinson disease (PD), epidemiological evidence on a possible effect of iron blood levels …

Background Dopamine agonists are being used increasingly as first line treatment for
Parkinson's disease, but there remains uncertainty about their clinical and cost …

Purpose Because the roles of striatal‐thalamo‐cortical and cerebello‐thalamo‐cortical
circuits in the heterogeneous motor impairments of Parkinson's disease (PD) are becoming …