[HTML][HTML] Anti-diabetic effects of sea cucumber (Holothuria nobilis) hydrolysates in streptozotocin and high-fat-diet induced diabetic rats via activating the PI3K/Akt …

T Wang, L Zheng, T Zhao, Q Zhang, Z Liu, X Liu… - Journal of Functional …, 2020 - Elsevier
In this study, anti-diabetic activity and potential mechanism of sea cucumber hydrolysates
(SCH) were investigated in type II diabetic rats induced by streptozotocin. Results showed …

[HTML][HTML] Anti-diabetic and anti-hyperlipidemic effects of sea cucumber (Cucumaria frondosa) gonad hydrolysates in type II diabetic rats

T Wang, L Zheng, S Wang, M Zhao, X Liu - Food Science and Human …, 2022 - Elsevier
The present study investigated the anti-diabetic activity and potential mechanisms of sea
cucumber gonad hydrolysates (SCGH) in a rat model of type II diabetes induced by …

[HTML][HTML] Sea cucumber (Holothuria nobilis) hydrolysates improve diabetic nephropathy via suppression of oxidative stress in high-fat diet/streptozotocin-induced …

T Wang, L Zheng, X Liu, M Zhao - Journal of Functional Foods, 2023 - Elsevier
Diabetic nephropathy (DN) is one of the most serious complications of diabetes. The
purpose of the present study was to investigate the renoprotective effects of sea cucumber …

Sea buckthorn fruit oil extract alleviates insulin resistance through the PI3K/Akt signaling pathway in type 2 diabetes mellitus cells and rats

S Gao, Q Guo, C Qin, R Shang… - Journal of agricultural and …, 2017 - ACS Publications
Sea buckthorn fruit oil is rich in palmitoleic acid (POA), which has been reported to play roles
in many metabolic processes. In this study, a sea buckthorn fruit oil (SBFO) extract was …

Fucosylated chondroitin sulfate from sea cucumber improves insulin sensitivity via activation of PI3K/PKB pathway

S Hu, Y Chang, M He, J Wang, Y Wang… - Journal of food …, 2014 - Wiley Online Library
This study was to investigate the effects of fucosylated chondroitin sulfate (CHS) from sea
cucumber on insulin sensitivity in skeletal muscle of type 2 diabetic mice induced by a high …

[HTML][HTML] Antidiabetic effects of a lipophilic extract obtained from flowers of Wisteria sinensis by activating Akt/GLUT4 and Akt/GSK3β

Y Lv, W Ren, Y Zhang, Y Huang, J Hao… - Food & Nutrition …, 2020 - ncbi.nlm.nih.gov
Background Type 2 diabetes mellitus is primarily caused by insulin resistance (IR) in insulin-
sensitive tissues, including liver, white adipose tissues (WAT), and skeletal muscles …

Aqueous extract of Polygonatum sibiricum ameliorates glucose and lipid metabolism via PI3K/AKT signaling pathway in high‐fat diet and streptozotocin‐induced …

G Wang, Z Liu, D Liang, J Yu, T Wang… - Journal of Food …, 2022 - Wiley Online Library
This study was aimed to investigate the protective effects and elucidate the mechanisms of
aqueous extract of Polygonatum sibiricum (PSAE) on glucolipid metabolism during the …

Anti-diabetic effect of oligosaccharides from seaweed Sargassum confusum via JNK-IRS1/PI3K signalling pathways and regulation of gut microbiota

C Yang, S Lai, Y Chen, D Liu, B Liu, C Ai, X Wan… - Food and Chemical …, 2019 - Elsevier
Brown seaweed Sargassum confusum (C. Agardh) has been used in traditional Chinese
medicine to treat a variety of diseases. The aim of the present study was to evaluate the anti …

[PDF][PDF] Seapolynol and dieckol improve insulin sensitivity through the regulation of the PI3K pathway in C57BL/KsJ-db/db mice

HJ Jeon, KY Yoon, EJ Koh, J Choi, KJ Kim, HS Choi… - J Food Nutr Res, 2015 - Citeseer
Ecklonia cava, a brown alga native to the seas of Korea and Japan, contains biologically
active polyphenols. Seapolynol (SN) is a polyphenol mixture derived from Ecklonia cava …

[HTML][HTML] Physicochemical characterization and hypoglycemic potential of a novel polysaccharide from Polygonatum sibiricum Red through PI3K/Akt mediated …

SZ Xie, WJ Zhang, W Liu, JB Bai, SL Xie… - Journal of Functional …, 2022 - Elsevier
The rhizome of Polygonatum sibiricum is traditionally used as a tonic-type edible herb. In
this study, a homogenous polysaccharide (PSPW) was isolated from P. sibiricum. PSPW …