Decline of antioxidant defense after estrogen deficiency leads to oxidative damage in bone
marrow-derived mesenchymal stem cells (BMMSCs), resulting a defect of bone formation in …

Uncontrolled oxidative stress impairs bone formation and induces age‐related bone loss in
humans. The FoxO family is widely accepted to play an important role in protecting diverse …

Accumulation of reactive oxygen species (ROS) induced by oxidative stress (OS) affects cell
survival, cell function and even results in cell death. As a major transcription factor of …

It is a great challenge to develop a safe and effective treatment strategy for age-related
osteoporosis and fracture healing. As one of the four FOXO transcription factors, FOXO1 is …

Forkhead box protein A2 (FOXA2) is a core transcription factor that controls cell
differentiation and may have an important role in bone metabolism. However, the role of …

FOXO transcription factors especially FOXO1 have profound roles in bone development and
remodeling. The regulation of cells of the osteoblast lineage by FOXOs is suggested to be …

Osteocyte plays an essential role in bone metabolism by regulating osteoblast and
osteoclast activities. Dysfunction or apoptosis of osteocyte will severely endanger the bone …

Aging increases oxidative stress and osteoblast apoptosis and decreases bone mass,
whereas forkhead box O (FoxO) transcription factors defend against oxidative stress by …

Several mechanisms contribute to the decline of all physiologic functions during aging. As a
consequence, disease incidence increases with age. Central to this multifactorial process is …

Abstract Resveratrol (3, 5, 4-trihydroxystilbene, RES), a natural antioxidant, prevents bone
loss by attenuating damage caused by oxidative stress. Our previous research revealed that …