To investigate the mechanisms of insulin resistance in obesity and noninsulin-dependent
diabetes mellitus (NIDDM), we examined oxidative and nonoxidative pathways of free fatty …

The objective of this study was to investigate to what extent disturbances in fatty acid
metabolism found in type 2 diabetes are already present in subjects at high risk for …

An increase in muscle lipid content has been postulated to relate closely to the evolution of
insulin resistance. We aimed to test whether the multiple indexes of lipid supply within man …

OBJECTIVE We have previously shown that overnight fasted women have higher insulin-
stimulated whole body and leg glucose uptake despite a higher intramyocellular …

In metabolically healthy humans, adipose tissue is exquisitely sensitive to insulin. Similar to
muscle and liver, adipose tissue lipolysis is insulin resistant in adults with central obesity …

Effects of circulating insulin and glucose concentrations on skeletal muscle and adipose
tissue lipolytic activity were investigated in 10 type 1 diabetes patients with no endogenous …

High fatty acid (FA) flux is associated with systemic insulin resistance, and African-American
(AA) women tend to be more insulin resistant. We assessed possible depot and race …

Physiologic elevations of plasma free fatty acid levels cause peripheral (muscle) insulin
resistance. They do this by inhibiting insulin stimulated glucose transport, phosphorylation …

Aims/hypothesis In the present study, we investigated the consequences of adipose tissue
lipolytic inhibition on skeletal muscle substrate use in type 2 diabetic patients. Materials and …

Elevation of plasma nonesterified fatty acid (NEFA) levels has been shown to impair the
actions of insulin on peripheral glucose uptake and suppression of hepatic glucose output …