We studied whether administration of nitric oxide (NO) donors reduces the ischemic damage
resulting from middle cerebral artery (MCA) occlusion in spontaneously hypertensive rats …

We used the nitric oxide (NO) donor sodium nitroprusside (SNP) and the NO synthase
inhibitor nitro-l-arginine methyl ester (l-NAME) to study the role of NO in the ischemic …

We studied whether delayed posttreatment with the nitric oxide donor 3-
morpholinosydnonimine (SIN-1) is effective in reducing the size of the infarct produced by …

Nitric oxide (NO) plays a dual role (neuroprotection and neurotoxicity) in cerebral ischemia.
NO promoting strategies may be beneficial shortly after ischemia. Therefore, we have …

OBJECTIVE: Deleterious effects of strokes may be ameliorated when thrombolysis (ie, with
recombinant tissue plasminogen activator) restores circulation. However, reperfusion injury …

Nitric oxide, a potent vasodilator and an inhibitor of platelet aggregation, may be beneficial
in the early stages of focal cerebral ischemia as it may facilitate collateral blood flow to the …

Using a porphyritic microsensor, we measured the cortical NO concentration within ischemic
tissue during 2 h of middle cerebral artery (MCA) occlusion and 1 h of reperfusion in the rat …

The efficacy of nitric oxide (NO) treatment in ischemic stroke, though well recognized, is yet
to be tested in clinic. NO donors used to treat ischemic injury are structurally diverse …

Nitric oxide (NO) increases 3′, 5′-cyclic guanosine monophosphate (cGMP) in vascular
smooth muscle and increases cerebral blood flow (CBF). In early stages of cerebral …

Cerebral ischemia initiates a cascade of detrimental events including glutamate‐associated
excitotoxicity, intracellular calcium accumulation, formation of Reactive oxygen species …