Significant progress in understanding and overcoming cardiac xenograft rejection using a
clinically relevant large animal pig-to-baboon model has accelerated in recent years. This …

Survival of pig cardiac xenografts in a non-human primate (NHP) model has improved
significantly over the last 4 years with the introduction of costimulation blockade-based …

Bauer A, Postrach J, Thormann M, Blanck S, Faber C, Wintersperger B, Michel S, Abicht J‐
M, Christ F, Schmitz C, Schmoeckel M, Reichart B, Brenner P. First experience with …

Cardiac xenotransplantation from swine has been proposed to “bridge the gap” in supply for
heart failure patients requiring transplantation. Recent preclinical success using genetically …

For many patients with terminal/advanced cardiac failure, heart transplantation is the most
effective, durable treatment option, and offers the best prospects for a high quality of life. The …

Objectives Cardiac transplantation and available mechanical alternatives are the only
possible solutions for end-stage cardiac disease. Unfortunately, because of the limited …

OBJECTIVES: Transplantation is limited by a lack of human organ donors. Organs derived
from animals, most likely the pig, represent a potential solution to this problem. For the heart …

If pig hearts could be transplanted successfully into patients with end-stage cardiac failure,
the critical shortage of hearts from deceased human donors would be overcome. The …

On January 7, 2022, in Baltimore, MD, USA, the XenoHeart team at the University of
Maryland School of Medicine (UMSOM) led by Dr. Muhammad Mohiuddin (President Elect …

Pig organs are at risk for hyperacute and acute vascular rejection mediated by anti-pig
antibodies, mainly binding to the Galα (1, 3) Gal epitope. Acute cellular rejection is …