Skeletal muscle requires a large increase in its ATP production to meet the energy needs of
exercise. Normally, most of this increase in ATP is supplied by the aerobic process of …

The ability to sustain submaximal exercise is largely dependent on the oxidative capacity of
mitochondria within skeletal muscle, and impairments in oxidative metabolism have been …

BACKGROUND Skeletal muscle metabolic abnormalities have been described in patients
with heart failure that are independent of total limb perfusion, histochemical changes, and …

The importance of measuring intracellular oxygen concentrations in tissues has, over the
years, emerged as a basic parameter in the physiology and biochemistry of living tissues …

Near‐infrared spectroscopy (NIRS) is a non‐invasive method for monitoring oxygen
availability and utilization by the tissues. In intact skeletal muscle, NIRS allows semi …

One of many problems to be faced when assessing in vivo human muscle mitochondria
respiration by phosphorus magnetic resonance spectroscopy (31 P-MRS) is the definition of …

The biochemical features of skeletal muscle and its contribution to exercise intolerance in
patients with chronic obstructive pulmonary disease (COPD) is under active investigation …

The assumption that cellular oxygen pressure (PO2) is close to zero in maximally exercising
muscle is essential for the hypothesis that O2 transport between blood and mitochondria has …

Exercise intolerance is one of the most common symptoms in patients with mitochondrial
myopathies (MM). At the whole body level, this is characterized by a reduction in maximal …