Macrophages play a key role in defending against foreign pathogens, healing wounds, and
regulating tissue homeostasis. Driving this versatility is their phenotypic plasticity, which …

Macrophages are prevalent in the body and have roles in almost every aspect of human
biology. They have often been considered a subject to avoid during drug delivery. However …

Introduction: Targeted drug delivery to the macrophages appears to be an attractive
proposition to improve therapeutic efficacy of enclosed drug. Thus, macrophages can be …

Macrophages have been extensively used in the development of drug delivery systems, as
they can prolong the circulation and release of drugs, extend their half-life, increase their …

Macrophages are cells of the innate immune system that are resident in all tissues, including
metabolic organs such as the liver and adipose tissue (AT). Because of their phenotypic …

Macrophages occupy a prominent position during immune responses. They are considered
the final effectors of any given immune response since they can be activated by a wide …

Introduction Macrophages are involved in the normal defense of the body; however, the
varying phenotypes of macrophages and imbalance in their ratio lead to the impairment of …

Highlights•Macrophage activation is best described by a multi-dimensional model.•Targeting
macrophages specifically requires a multi-modal approach.•Macrophage reprogramming …

Macrophages are versatile and plastic effector cells of the immune system, and contribute to
diverse immune functions including pathogen or apoptotic cell removal, inflammatory …

Introduction: Drug targeting to sites of tissue injury, tumor or infection with limited toxicity is
the goal for successful pharmaceutics. Immunocytes (including mononuclear phagocytes …