[PDF][PDF] Cell-based drug delivery devices using phagocytosis-resistant backpacks

MF Rubner, S Mitragotri - Adv Mater, 2011 - academia.edu
Macrophages, ubiquitous phagocytic cells in the human immune system, play a key role in
homeostatic, immunological, and inflammatory processes.[1–2] Macrophages are widely …

Delivery strategies to control inflammatory response: Modulating M1–M2 polarization in tissue engineering applications

MM Alvarez, JC Liu, G Trujillo-de Santiago… - Journal of Controlled …, 2016 - Elsevier
Macrophages are key players in many physiological scenarios including tissue
homeostasis. In response to injury, typically the balance between macrophage sub …

Neutrophils and macrophages as targets for development of nanotherapeutics in inflammatory diseases

Y Su, J Gao, P Kaur, Z Wang - Pharmaceutics, 2020 - mdpi.com
Neutrophils and macrophages are major components of innate systems, playing central
roles in inflammation responses to infections and tissue injury. If they are out of control …

Living leukocyte‐based drug delivery systems

Y Chen, D Qin, J Zou, X Li, XD Guo, Y Tang… - Advanced …, 2023 - Wiley Online Library
Leukocytes play a vital role in immune responses, including defending against invasive
pathogens, reconstructing impaired tissue, and maintaining immune homeostasis. When the …

Sequential drug delivery to modulate macrophage behavior and enhance implant integration

EM O'Brien, GE Risser, KL Spiller - Advanced drug delivery reviews, 2019 - Elsevier
Macrophages are major upstream regulators of the inflammatory response to implanted
biomaterials. Sequential functions of distinct macrophage phenotypes are essential to the …

Chemical Modulation of in Vivo Macrophage Function with Subpopulation-Specific Fluorescent Prodrug Conjugates

A Fernandez, M Vermeren, D Humphries… - ACS Central …, 2017 - ACS Publications
Immunomodulatory agents represent one of the most promising strategies for enhancing
tissue regeneration without the side effects of traditional drug-based therapies. Tissue repair …

Nanoparticle‐laden macrophages for tumor‐tropic drug delivery

W Zhang, M Wang, W Tang, R Wen, S Zhou… - Advanced …, 2018 - Wiley Online Library
Macrophages hold great potential in cancer drug delivery because they can sense
chemotactic cues and home to tumors with high efficiency. However, it remains a challenge …

Nanoparticles targeting macrophages as potential clinical therapeutic agents against cancer and inflammation

G Hu, M Guo, J Xu, F Wu, J Fan, Q Huang… - Frontiers in …, 2019 - frontiersin.org
With the development of nanotechnology, significant progress has been made in the design,
and manufacture of nanoparticles (NPs) for use in clinical treatments. Recent increases in …

Macrophages as tools and targets in cancer therapy

A Mantovani, P Allavena, F Marchesi… - Nature Reviews Drug …, 2022 - nature.com
Tumour-associated macrophages are an essential component of the tumour
microenvironment and have a role in the orchestration of angiogenesis, extracellular matrix …

Mechanobiology of macrophages: how physical factors coregulate macrophage plasticity and phagocytosis

N Jain, J Moeller, V Vogel - Annual review of biomedical …, 2019 - annualreviews.org
In addition to their early-recognized functions in host defense and the clearance of apoptotic
cell debris, macrophages play vital roles in tissue development, homeostasis, and repair. If …