Background Hypoxia-inducible factors (HIF) 1 and 2 are transcription factors that regulate
the homeostatic response to low oxygen conditions. Since data related to the importance of …

Although it has been shown that HIF1 and 2 fulfill essential roles within the hematopoietic
system and in the regulation of HSC fate, little is currently known about the specific …

To cope with hypoxic stress, ancient organisms have developed evolutionally conserved
programs centered on hypoxia-inducible transcriptional factors (HIFs). HIFs and their …

Hypoxia (low O 2) is a fundamental microenvironmental determinant of bone marrow (BM)
pathophysiology. Recent data from molecular and clinical studies indicate that …

Abstract Background HIF1A (Hypoxia-Inducible-Factor 1A) expression in solid tumors is
relevant to establish resistance to therapeutic approaches. The use of compounds direct …

Hypoxia describes limited oxygen availability at the cellular level. Myeloid cells are exposed
to hypoxia at various bodily sites and even contribute to hypoxia by consuming large …

Background Adult hematopoietic stem cells (HSCs) are maintained in a microenvironment,
known as niche in the endosteal regions of the bone marrow. This stem cell niche with low …

Hypoxia-inducible factor (HIF) regulates the major transcriptional cascade central to the
response of all mammalian cells to alterations in oxygen tension. Expression arrays indicate …

The hypoxia-inducible factor 1 (HIF-1), in addition to genetic and epigenetic changes, is
largely responsible for alterations in cell metabolism in hypoxic tumor cells. This …

Leukemogenesis occurs under hypoxic conditions within the bone marrow (BM).
Knockdown of key mediators of cellular responses to hypoxia with shRNA, namely hypoxia …