SARS-CoV-2 spike T cell responses induced upon vaccination or infection remain robust against Omicron
R Keeton, MB Tincho, A Ngomti, R Baguma, N Benede… - MedRxiv, 2021 - medrxiv.org
Summary The SARS-CoV-2 Omicron variant has multiple Spike (S) protein mutations that
contribute to escape from the neutralizing antibody responses, and reducing vaccine …
contribute to escape from the neutralizing antibody responses, and reducing vaccine …
T cell responses to SARS-CoV-2 spike cross-recognize Omicron
R Keeton, MB Tincho, A Ngomti, R Baguma, N Benede… - Nature, 2022 - nature.com
Abstract The SARS-CoV-2 Omicron variant (B. 1.1. 529) has multiple spike protein
mutations, that contribute to viral escape from antibody neutralization,,–and reduce vaccine …
mutations, that contribute to viral escape from antibody neutralization,,–and reduce vaccine …
[PDF][PDF] T cell reactivity to the SARS-CoV-2 Omicron variant is preserved in most but not all individuals
Summary The SARS-CoV-2 Omicron variant (B. 1.1. 529) contains mutations that mediate
escape from antibody responses, although the extent to which these substitutions in spike …
escape from antibody responses, although the extent to which these substitutions in spike …
Immunosequencing and epitope mapping reveal substantial preservation of the T cell immune response to Omicron generated by SARS-CoV-2 vaccines
Abstract The Omicron SARS-CoV-2 variant contains 34 mutations in the spike gene likely
impacting protective efficacy from vaccines. We evaluated the potential impact of these …
impacting protective efficacy from vaccines. We evaluated the potential impact of these …
SARS-CoV-2 T cell responses elicited by COVID-19 vaccines or infection are expected to remain robust against Omicron
Omicron, the most recent SARS-CoV-2 variant of concern (VOC), harbours multiple
mutations in the spike protein that were not observed in previous VOCs. Initial studies …
mutations in the spike protein that were not observed in previous VOCs. Initial studies …
[HTML][HTML] SARS-CoV-2 Omicron neutralization by therapeutic antibodies, convalescent sera, and post-mRNA vaccine booster
The rapid spread of the highly contagious Omicron variant of SARS-CoV-2 along with its
high number of mutations in the spike gene has raised alarm about the effectiveness of …
high number of mutations in the spike gene has raised alarm about the effectiveness of …
[HTML][HTML] Vaccines elicit highly cross-reactive cellular immunity to the SARS-CoV-2 omicron variant
J Liu, A Chandrashekar, D Sellers, J Barrett, M Lifton… - MedRxiv, 2022 - ncbi.nlm.nih.gov
The highly mutated SARS-CoV-2 Omicron (B. 1.1. 529) variant has been shown to evade a
substantial fraction of neutralizing antibody responses elicited by current vaccines that …
substantial fraction of neutralizing antibody responses elicited by current vaccines that …
Reduced neutralization of SARS-CoV-2 Omicron variant by vaccine sera and monoclonal antibodies
Due to numerous mutations in the spike protein, the SARS-CoV-2 variant of concern
Omicron (B. 1.1. 529) raises serious concerns since it may significantly limit the antibody …
Omicron (B. 1.1. 529) raises serious concerns since it may significantly limit the antibody …
SARS-CoV-2 Omicron spike mediated immune escape and tropism shift
B Meng, IATM Ferreira, A Abdullahi, N Goonawardane… - BioRxiv, 2021 - biorxiv.org
Abstract The SARS-CoV-2 Omicron BA. 1 variant emerged in late 2021 and is characterised
by multiple spike mutations across all spike domains. Here we show that Omicron BA. 1 has …
by multiple spike mutations across all spike domains. Here we show that Omicron BA. 1 has …
[HTML][HTML] Neutralization and stability of SARS-CoV-2 Omicron variant
Abstract The SARS-CoV-2 B. 1.1. 529/Omicron variant was first characterized in South Africa
and was swiftly designated a variant of concern 1. Of great concern is its high number of …
and was swiftly designated a variant of concern 1. Of great concern is its high number of …