A major mechanism in the cellular defense against oxidative or electrophilic stress is
activation of the Nrf2-antioxidant response element signaling pathway, which controls the …

Several years have passed since NF-E2-related factor 2 (Nrf2) was demonstrated to
regulate the induction of genes encoding antioxidant proteins and phase 2 detoxifying …

Oxidative stress causes damage to multiple cellular components such as DNA, proteins, and
lipids, and is implicated in various human diseases including cancer, neurodegeneration …

Abstract The Keap1-Nrf2 system plays pivotal roles in defense mechanisms by regulating
cellular redox homeostasis. Nrf2 is an inducible transcription factor that activates a battery of …

Animals have evolved defense systems for surviving in a chemically diverse environment.
Such systems should demonstrate plasticity, such as adaptive immunity, enabling a …

ABSTRACT NF‐E2‐related factor 2 (Nrf2) is a basic leucine zipper transcription factor that
binds to the promoter sequence “antioxidant responsive element (ARE)” leading to …

Keap1 is a negative regulator of Nrf2, a bZIP transcription factor that mediates adaptation to
oxidative stress. Previous studies suggested this negative regulation is a consequence of …

To maintain intracellular redox homeostasis, genes encoding many antioxidants and
detoxification enzymes are transcriptionally upregulated upon deleterious oxidative stress …

Publisher Summary This chapter examines Nrf2 and other cap “n” collar (CNC) family factors—
namely Nrf1 and Nrf3, which cross-talk with the Nrf2–Keap1 regulatory pathway. The …

Since eukaryotic cells constantly encounter various environmental insults, they have
evolved defense mechanisms to cope with toxicant-and carcinogen-induced oxidative stress …