Human exposures to environmental toxicants have been associated with etiology of many
diseases including inflammation, cancer, and cardiovascular and neurodegenerative …

Antioxidant response element (ARE)-mediated expression and coordinated induction of
antioxidant enzymes is a critical mechanism of protection against chemically induced …

Transcriptional activation of protective genes is mediated by a cis‐acting element called the
antioxidant responsive element (ARE). The transcription factor Nrf2 (NF–E2‐related factor 2) …

Nuclear factor E2–related factor 2 (Nrf2) is a transcription factor known to induce expression
of a variety of cytoprotective and detoxification genes. Several of the genes commonly …

Transcription factor Nrf2 is essential for the antioxidant responsive element (ARE)-mediated
induction of phase II detoxifying and oxidative stress enzyme genes. Detailed analysis of …

The induction of many antioxidant and phase II drug-metabolizing enzymes by phenolic
antioxidants and electrophilic compounds is regulated at the transcriptional level. The …

The KEAP1-NRF2 system plays a central role in cytoprotection. NRF2 is stabilized in
response to electrophiles and activates transcription of antioxidant genes. Although robust …

Nrf2 (NF-E2-related factor 2) is a central transcription factor involved in the transcriptional
activation of many genes encoding phase II drug-metabolizing enzymes via the antioxidant …

Modulation of NF-E2 related factor 2 (Nrf2) has been shown in several neurodegenerative
disorders. The overexpression of Nrf2 has become a potential therapeutic avenue for …

Nrf2, a basic leucine zipper transcription factor, is an essential activator of the coordinated
transcription of genes encoding antioxidant enzymes and phase II detoxifying enzymes …