Nrf2 is a key transcription factor in the cellular response to oxidative stress. In this study we
identify two phosphorylated forms of endogenous human Nrf2 after chemically induced …

Abstract Nrf2: INrf2 (Keap1) are cellular sensors of oxidative and electrophilic stress. Nrf2 is
a nuclear factor that controls the expression and coordinated induction of a battery of genes …

Cells respond to oxidants and electrophiles by activating receptor/transcription factor
nuclear factor erythroid 2-related factor 2 (Nrf2) to coordinate the induction of cytoprotective …

Abstract Nuclear Factor Erythroid 2-related factor 2 (Nrf2) is a transcription factor that
regulates the expression of genes involved in the metabolism, immune response, cellular …

Abstract Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) regulates the basal and stress-
inducible expression of a battery of genes encoding key components of the glutathione …

The nuclear factor erythroid 2 related factor 2 (NRF2) is a key regulator of endogenous
inducible defense systems in the body. Under physiological conditions NRF2 is mainly …

The transcription factor Nrf2 regulates cellular redox homeostasis. Under basal conditions,
Keap1 recruits Nrf2 into the Cul3-containing E3 ubiquitin ligase complex for ubiquitin …

Adverse drug reactions pose a significant public health problem. In some cases, the process
of drug metabolism can contribute to the onset of toxicity through the bioactivation of a …

Publisher Summary This chapter outlines the role of Nrf2 in the activation of antioxidation
enzyme via antioxidant responsive element/electrophile responsive element (ARE/EpRE) …

Human exposures to environmental toxicants have been associated with development of a
number of diseases. Animal experiments have identified a number of cytoprotective …