The NF-E2-related factor 2 (Nrf2) is a key transcriptional regulator of antioxidant defense
and detoxification. To directly monitor stabilization of Nrf2, we fused its Neh2 domain …

For the past 40years or so, oxidative stress has been increasingly recognized as a
contributing factor in aging and in various forms of pathophysiology generally associated …

Nrf1 and Nrf2 are members of the CNC family of bZIP transcription factors that exhibit
structural similarities, and they are co-expressed in a wide range of tissues during …

Nrf2 regulates the expression of genes encoding antioxidant proteins involved in cellular
redox homeostasis. Previous studies have suggested that activation of Nrf2 is mediated by …

The Nrf2 transcription factor governs the expression of hundreds genes involved in cell
defense against oxidative stress, the hallmark of numerous diseases such as …

The nuclear factor erythroid 2-related factor 2 (NRF2) was originally described as a master
regulator of antioxidant cellular response, but in the time since, numerous important …

Prophylactic pharmacological activation of astrocytic gene expression driven by the
transcription factor Nrf2 boosts antioxidant defences and protects against neuronal loss in …

NRF2 (nuclear factor erythroid 2-related factor 2) is a key transcriptional activator that
mediates the inducible expression of antioxidant genes. NRF2 is normally ubiquitinated by …

Oxidative stress is the increase in cellular oxidant concentration in comparison to antioxidant
titer. Toxic insults and many other diseased conditions are mediated through the formation of …

The antioxidant response element (ARE) is a cis-acting regulatory enhancer element found
in the 5′ flanking region of many phase II detoxification enzymes. Up-regulation of ARE …