Abstract Background: The transcription factor Nrf2 and its negative regulator Keap1 play
important roles in transcriptional induction of a set of detoxifying and anti‐oxidant enzymes …

The antioxidant response element (ARE) is a cis-acting regulatory enhancer element found
in the 5′ flanking region of many phase II detoxification enzymes. Up-regulation of ARE …

Prophylactic pharmacological activation of astrocytic gene expression driven by the
transcription factor Nrf2 boosts antioxidant defences and protects against neuronal loss in …

Simple Summary Transcription factor NRF2 controls expression of antioxidant and
detoxification genes. Normally, the activity of NRF2 is tightly controlled in the cell, and is …

Neurodegenerative diseases share various pathological features, such as accumulation of
aberrant protein aggregates, microglial activation, and mitochondrial dysfunction. These …

Electrophile responsive element (EpRE)-mediated gene induction is a pivotal mechanism of
cellular defense against the toxicity of electrophiles and reactive oxygen species (ROS) …

Oxidative stress is the increase in cellular oxidant concentration in comparison to antioxidant
titer. Toxic insults and many other diseased conditions are mediated through the formation of …

The antioxidant responsive element (ARE) is a cis-acting regulatory element located in the
5′-flanking region of several genes encoding phase II detoxification enzymes, including …

Nrf2 and its endogenous inhibitor, Keap1, function as a ubiquitous, evolutionarily conserved
intracellular defense mechanism to counteract oxidative stress. Sequestered by cytoplasmic …

Nuclear factor erythroid 2-related factor 2 (Nrf2) coordinates the up-regulation of
cytoprotective genes via the antioxidant response element (ARE). In the pathogenesis of …