[HTML][HTML] Lynch syndrome pre-screening and comprehensive characterization in a multi-center large cohort of Chinese patients with colorectal cancer
Y Li, L Fan, J Zheng, X Nie, Y Sun, Q Feng… - Cancer biology & …, 2022 - ncbi.nlm.nih.gov
Objective: Lynch syndrome (LS) pre-screening methods remain under-investigated in
colorectal cancers (CRCs) in Asia. Here, we aimed to systematically investigate LS pre …
colorectal cancers (CRCs) in Asia. Here, we aimed to systematically investigate LS pre …
It is time to get serious about diagnosing Lynch syndrome (hereditary nonpolyposis colorectal cancer with defective DNA mismatch repair) in the general population
JP Terdiman - Gastroenterology, 2005 - gastrojournal.org
MD, a pioneer in the field, is an autosomal dominant hereditary cancer syndrome, which
accounts for upwards of 3% of all colorectal cancers, 1, 2 and is associated with an …
accounts for upwards of 3% of all colorectal cancers, 1, 2 and is associated with an …
[HTML][HTML] Risk Factors Associated with Colorectal Cancer in a Subset of Patients with Mutations in MLH1 and MSH2 in Taiwan Fulfilling the Amsterdam II Criteria for …
AB Kamiza, LL Hsieh, R Tang, HT Chien, CH Lai… - PLoS …, 2015 - journals.plos.org
Background and Aim Lynch syndrome, caused by germline mutations in mismatch repair
genes, is a predisposing factor for colorectal cancer (CRC). This retrospective cohort study …
genes, is a predisposing factor for colorectal cancer (CRC). This retrospective cohort study …
The International Mismatch Repair Consortium
Abstract The International Mismatch Repair Consortium (IMRC) is a collaboration of
clinicians and scientists who have agreed to pool and analyse data on Lynch syndrome, a …
clinicians and scientists who have agreed to pool and analyse data on Lynch syndrome, a …
[HTML][HTML] Teenage colorectal polyposis and cancer may be caused by constitutional mismatch repair deficiency (CMMRD)
J Soplepmann, P Laidre - Acta Oncologica, 2016 - Taylor & Francis
Lynch syndrome is the most common hereditary colorectal cancer (CRC) syndrome [1]. It is
an autosomal dominant condition with mutations in the DNA mismatch repair (MMR) genes …
an autosomal dominant condition with mutations in the DNA mismatch repair (MMR) genes …
Implementing population-based screening for Lynch syndrome.
6600 Background: A myriad of molecular markers has been proposed and tested with the
promise of improving cancer care. Few have been validated and even fewer have been …
promise of improving cancer care. Few have been validated and even fewer have been …
Microsatellite instability and novel mismatch repair gene mutations in northern Chinese population with Hereditary non‐polyposis colorectal cancer
JQ Sheng, TL Chan, YW Chan… - Chinese journal of …, 2006 - Wiley Online Library
OBJECTIVE: Hereditary non‐polyposis colorectal cancer (HNPCC) syndrome is the most
common cause of hereditary colorectal cancer with an early age of onset. Microsatellite …
common cause of hereditary colorectal cancer with an early age of onset. Microsatellite …
[HTML][HTML] Penetrance of colorectal cancer among MLH1/MSH2 carriers participating in the colorectal cancer familial registry in Ontario
YH Choi, M Cotterchio, G McKeown-Eyssen… - Hereditary cancer in …, 2009 - Springer
Background Several DNA mismatch repair (MMR) genes, responsible for the majority of
Lynch Syndrome cancers, have been identified, predominantly MLH1 and MSH2, but the …
Lynch Syndrome cancers, have been identified, predominantly MLH1 and MSH2, but the …
Microsatellite instability in colorectal adenomas and hyperplastic polyps in Lynch syndrome
Background Lynch syndrome is characterized by germline mutations in DNA mismatch
repair (MMR) genes and carries up to a 70% lifetime risk of colorectal cancer. Impaired MMR …
repair (MMR) genes and carries up to a 70% lifetime risk of colorectal cancer. Impaired MMR …
Analysis of mismatch repair gene mutations in Turkish HNPCC patients
Hereditary non-polyposis colorectal cancer (HNPCC or Lynch syndrome) is caused by the
inheritance of a mutant allele of a DNA mismatch repair gene. We aimed to investigate types …
inheritance of a mutant allele of a DNA mismatch repair gene. We aimed to investigate types …