Background: Patients with early-onset colorectal cancer (CRC) or those with multiple
tumours associated with hereditary non-polyposis colorectal cancer (HNPCC) raise …

Abstract Background and Aims: Lynch syndrome is caused by germ-line mismatch repair
gene mutations. We examined the phenotypic differences between MLH1 and MSH2 gene …

Lynch syndrome (LS) is the most common form of hereditary colon cancer. Germline
mutations in the mismatch-repair (MMR) genes MLH1, MSH2 (EPCAM), MSH6, and PMS2 …

ContextThe accurate identification and interpretation of germline mutations in mismatch
repair genes in colorectal cancer cases is critical for clinical management. Current data …

Mismatch repair (MMR) malfunction causes the accumulation of mismatches in the genome
leading to genomic instability and cancer. The inactivation of an MMR gene (MSH2, MSH6 …

Mismatch repair (MMR) genes are among of the most important genes associated with
colorectal cancer (CRC). Single-nucleotide polymorphisms (SNPs) are generally thought to …

Background Preventive programs for individuals who have high lifetime risks of colorectal
cancer may reduce disease morbidity and mortality. Thus, it is important to identify the …

Background Lynch syndrome (LS) is caused by heterozygous germline mutations in the
DNA mismatch repair (MMR) genes and is a highly penetrant autosomal dominant condition …

Background Lynch syndrome (LS) is caused by germline mismatch repair (MMR) gene
mutations. De novo MMR gene mutations are rare, and somatic mosaicism in LS is thought …

Lynch syndrome (LS) is an autosomal dominant genetic disorder associated with germline
mutations in DNA mismatch repair (MMR) genes. The carriers of pathogenic mutations in …