Negative and positive promoter elements contribute to tissue specificity of apolipoprotein B expression

P Carlsson, G Bjursell - Gene, 1989 - Elsevier
Apolipoprotein B (ApoB) is a major constituent of the plasma lipoproteins. In adult mammals
it is synthesized in two different tissues, liver and intestine. We have examined the promoter …

Cloning and regulation of rat apolipoprotein B mRNA

A Matsumoto, H Aburatani, Y Shibasaki… - Biochemical and …, 1987 - Elsevier
Recombinant cDNA clones that code for apolipoprotein B (apoB) were isolated from a rat
liver cDNA library, using synthetic oligonucleotide probe derived from the sequence of …

Similarities and differences in the function of regulatory elements at the 5'end of the human apolipoprotein B gene in cultured hepatoma (HepG2) and colon carcinoma …

B Paulweber, MA Onasch, BP Nagy… - Journal of Biological …, 1991 - ASBMB
The arrangement of regulatory elements along the apolipoprotein B promoter region
(positions-898 to+ 1) has been examined in transient transfection experiments performed in …

Transcriptional control of the human apolipoprotein B gene in cell culture and in transgenic animals

B Levy-Wilson - Progress in nucleic acid research and molecular …, 1995 - Elsevier
Publisher Summary Transcriptional Control of the Human Apolipoprotein B Gene in Cell
Culture and in This chapter discusses the recent progress in three major areas of work, with …

Cell type-specific expression of the human apoB gene is controlled by two cis-acting regulatory regions.

HK Das, T Leff, JL Breslow - Journal of Biological Chemistry, 1988 - ASBMB
The human apolipoprotein B (apoB) gene codes for two related proteins, apoB-100 and
apoB-48. ApoB-100 is synthesized in the liver, is the major protein constituent of low density …

The mechanisms by which a human apolipoprotein B gene enhancer and reducer interact with the promoter are different in cultured cells of hepatic and intestinal …

B Paulweber, B Levy-Wilson - Journal of Biological Chemistry, 1991 - ASBMB
In the preceding paper (Paulweber, B., Onasch, MA, Nagy, BP, and Levy-Wilson, B.(1991) J.
Biol. Chem. 266, 24149-24160) we demonstrated that the segment of the apolipoprotein B …

Human apolipoprotein B: identification of cDNA clones and characterization of mRNA

M Mehrabian, VN Schumaker, GC Fareed… - Nucleic Acids …, 1985 - academic.oup.com
Apolipoprotein B (apoB) is a major protein component of low density and very low density
lipoproteins. Because of its large size and heterogeneity, molecular studies of apoB have …

Human apolipoprotein B gene intestinal control region

TJ Antes, SA Goodart, W Chen, B Levy-Wilson - Biochemistry, 2001 - ACS Publications
Recently, we reported that a 315 bp enhancer, located over 55 kilobases (kb) upstream of
the transcriptional start site of the human apolipoprotein B (apoB) gene, was sufficient to …

[HTML][HTML] The apolipoprotein B gene is constitutively expressed in HepG2 cells: regulation of secretion by oleic acid, albumin, and insulin, and measurement of the …

CR Pullinger, JD North, BB Teng, VA Rifici… - Journal of Lipid …, 1989 - Elsevier
The objective of this study was to establish conditions whereby apoB secreted from HepG2
cells could be regulated over a wide range, and to determine whether changes of output …

Identification and characterization of a 315-base pair enhancer, located more than 55 kilobases 5′ of the apolipoprotein B gene, that confers expression in the …

TJ Antes, SA Goodart, C Huynh, M Sullivan… - Journal of Biological …, 2000 - ASBMB
We recently reported that an 8-kilobase (kb) region, spanning from− 54 to− 62 kb 5′ of the
human apolipoprotein B (apoB) gene, contains intestine-specific regulatory elements that …