AGPAT6 is a member of the 1-acylglycerol-3-phosphate O-acyltransferase (AGPAT) family
that appears to be important in triglyceride biosynthesis in several tissues, but the precise …

Glycerophospholipids and triglycerides are synthesized de novo by cells through an
evolutionary conserved process involving serial acylations of phosphorylated glycerol …

Loss-of-function mutations in 1-acylglycerol-3-phosphate O-acyltransferase (AGPAT) 2 in
humans and mice result in loss of both the white and brown adipose tissues from birth …

Most cells synthesize their glycerophospholipids and triglycerides (TG) to maintain the
cellular integrity and to provide energy for cellular functions. The phospholipids are …

Synthesis of phospholipids can occur de novo or via remodeling of the existing
phospholipids. Synthesis of triglycerides, a form of energy storage in cells, is an end product …

The 1-Acylglycerolphosphate acyltransferase is crucial enzyme for synthesis of glycerolipids
as well as triacylglylcerol biosynthesis in eukaryotes. Six members of 1-acyl-sn-glycerol-3 …

Acyl-CoA: glycerol-3-phosphate acyltransferase (GPAT) catalyzes the first step during de
novo synthesis of triacylglycerol. It has been well recognized that mammals possess multiple …

Acyl-CoA: glycerol-3-phosphate acyltransferase (GPAT) catalyzes the first step during de
novo synthesis of glycerolipids. Mammals have at least four GPAT isoforms. Here we report …

Elucidation of the metabolic pathways of triacylglycerol (TAG) synthesis is critical to the
understanding of chronic metabolic disorders such as obesity, cardiovascular disease, and …

Glycerol-3-phosphate acyltransferases (GPATs) catalyze the first step in the synthesis of
glycerolipids and glycerophospholipids. Microsomal GPAT, the major GPAT activity, is …