In vitro effects of NIPRISAN (Nix‐0699): a naturally occurring, potent antisickling agent
EW Iyamu, EA Turner, T Asakura - British journal of …, 2002 - Wiley Online Library
Among the various potential antisickling agents tested, hydroxyurea (HU) has been the most
effective compound used for the treatment of patients with sickle cell disease (SCD) …
effective compound used for the treatment of patients with sickle cell disease (SCD) …
Mechanisms of homogeneous nucleation of polymers of sickle cell anemia hemoglobin in deoxy state
O Galkin, PG Vekilov - Journal of molecular biology, 2004 - Elsevier
The primary pathogenic event of sickle cell anemia is the polymerization of the mutant
hemoglobin (Hb) S within the red blood cells, occurring when HbS is in deoxy state in the …
hemoglobin (Hb) S within the red blood cells, occurring when HbS is in deoxy state in the …
The effects of erythrocyte membranes on the nucleation of sickle hemoglobin
A Aprelev, MA Rotter, Z Etzion, RM Bookchin… - Biophysical journal, 2005 - cell.com
Pathology in sickle cell disease begins with nucleation-dependent polymerization of
deoxyhemoglobin S into stiff, rodlike fibers that deform and rigidify red cells. We have …
deoxyhemoglobin S into stiff, rodlike fibers that deform and rigidify red cells. We have …
Management of patients with sickle cell disease.
R Steingart - The medical clinics of North America, 1992 - europepmc.org
The ever-increasing body of information regarding the molecular pathogenesis of sickle cell
disease has raised expectations that a specific and effective therapy could be devised to …
disease has raised expectations that a specific and effective therapy could be devised to …
Evaluation of HEPES and phosphate buffers for rheological studies of sickle cells
AJ Keidan, MC Sowter, SS Marwah… - Clinical …, 1987 - content.iospress.com
Determination of the optimal buffer for rheological studies of sickle cells is of particular
importance for in vitro screening of potential anti-sickling compounds and for ex vivo studies …
importance for in vitro screening of potential anti-sickling compounds and for ex vivo studies …
Hypoxia-induced in vivo sickling of transgenic mouse red cells.
EM Rubin, HE Witkowska, E Spangler… - The Journal of …, 1991 - Am Soc Clin Investig
To develop an animal model for sickle cell anemia, we have created transgenic mice that
express a severe naturally occurring human sickling hemoglobin, Hb S Antilles. Due to its …
express a severe naturally occurring human sickling hemoglobin, Hb S Antilles. Due to its …
Sickle cell disease: advances in treatment
RV Gardner - Ochsner journal, 2018 - ochsnerjournal.org
Background: Sickle cell disease causes significant morbidity and mortality and affects the
economic and healthcare status of many countries. Yet historically, the disease has not had …
economic and healthcare status of many countries. Yet historically, the disease has not had …
Recent advances in the treatment of sickle cell disease
G Salinas Cisneros, SL Thein - Frontiers in physiology, 2020 - frontiersin.org
Sickle cell anemia (SCA) was first described in the Western literature more than 100 years
ago. Elucidation of its molecular basis prompted numerous biochemical and genetic studies …
ago. Elucidation of its molecular basis prompted numerous biochemical and genetic studies …
Ektacytometric measurement of sickle cell deformability as a continuous function of oxygen tension [published erratum appears in Blood 1987 Apr; 69 (4): 1272]
MP Sorette, MG Lavenant, MR Clark - 1987 - ashpublications.org
In an effort to study the rheologic effects of small amounts of hemoglobin S (HbS) polymer in
sickle red cells, we have used the ektacytometer, a laser diffraction couette viscometer, to …
sickle red cells, we have used the ektacytometer, a laser diffraction couette viscometer, to …