Objectives Adipsin, or complement factor D, is a serine proteinase catalysing complement
factor C3 breakdown, leading to the production of opsonin (C3b), membrane attack complex …

Objective Adipose tissues secrete adipokines, peptides with potent effects modulating
fibrosis, inflammation, and vascular homeostasis. Dysregulated adipose tissue biology and …

Scleroderma is a systemic autoimmune disease of unknown etiology whose hallmark
features include endothelial cell dysfunction, fibroblast proliferation and immune …

Scleroderma is a systemic autoimmune disease of unknown etiology whose characteristic
features include endothelial cell dysfunction, fibroblast proliferation, and immune …

Obesity is a potent risk factor for atherosclerotic morbidity and mortality. Cytokines secreted
from adipose tissue, namely, adipokines, have been suggested to be actively involved in …

Adipsin is an adipokine predominantly synthesized in adipose tissues and released into
circulation. It is also known as complement factor-D (CFD), acting as the rate-limiting factor …

Purpose Adipokines belong to a group of molecules mostly produced by adipose tissue.
Abnormalities in the secretion of several adipokines have already implicated to play a …

Objectives The immunomodulatory properties of adipokines have previously been reported
in autoimmune disorders. Less is known about the role of adipokines in systemic sclerosis …

Systemic sclerosis (SSc), or scleroderma, is a multisystem autoimmune disorder
characterized by vasculopathy and fibrosis in the skin and internal organs, most frequently in …

Systemic sclerosis (SSc) is a chronic autoimmune connective tissue disease with
manifestations in multiple organs, including the skin, lung, heart, joints, gastrointestinal tract …